Results 41 to 50 of about 8,916 (246)
Frontiers in Immunology, 2022 BackgroundAllergic asthma is a chronic disease and medical treatment often fails to fully control the disease in the long term, leading to a great need for new therapeutic approaches.
Franziska Oliveri +6 more
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The Immunoproteasome as a Target in Hematologic Malignancies [PDF]
Seminars in Hematology, 2012 Suppression of proteasome function with the first-in-class small molecule inhibitor bortezomib is a rational therapeutic strategy against several hematologic malignancies, including multiple myeloma and mantle cell lymphoma. Second-generation inhibitors such as carfilzomib, ixazomib, and marizomib that, like bortezomib, target both the constitutive ...
Deborah J, Kuhn, Robert Z, Orlowski
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Cells, 2021 Proteasomes are intracellular structures responsible for protein degradation. The 20S proteasome is a core catalytic element of the proteasome assembly.
Elmira Vagapova +8 more
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Fluorescence-based proteasome activity profiling [PDF]
, 2012 With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Berkers, C.R. +4 more
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Dysfunctional immunoproteasomes in autoinflammatory diseases [PDF]
Inflammation and Regeneration, 2016 Recent progress in DNA sequencing technology has made it possible to identify specific genetic mutations in familial disorders. For example, autoinflammatory syndromes are caused by mutations in gene coding for immunoproteasomes. These diseases include Japanese autoinflammatory syndrome with lipodystrophy, Nakajo-Nishimura syndrome, joint contractures,
Arimochi, Hideki +3 more
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Immunoproteasomes: Regulating the regulator [PDF]
Proceedings of the National Academy of Sciences, 2005 I f proteins were people, half of the world's population (3 × 109) would cohabit, cheek by jowl, the typically sized vertebrate cell. Proteins are the most abundant macromolecular constituent of cells and certainly the most important and interesting. Because the interactions of proteins with each other and other cellular components are governed by the ...
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Regulation of the neuronal proteasome by Zif268 (Egr1) [PDF]
, 2006 Most forms of neuronal plasticity are associated with induction of the transcription factor Zif268 (Egr1/Krox24/NGF-IA). In a genomewide scan, we obtained evidence for potential modulation of proteasome subunit and regulatory genes by Zif268 in neurons,
Conway, A.M., James, A.B., Morris, B.J.
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Immunoproteasome deficiency modifies the alternative pathway of NFκB signaling. [PDF]
PLoS ONE, 2013 Immunoproteasome is a protease abundant in immune cells and also present, albeit at lower concentrations, in cells outside the immune system. Recent evidence supports a novel role for the immunoproteasome in the cellular stress response potentially ...
Marcela Maldonado +6 more
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Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors
Cells, 2021 Inhibitors of the proteolytic activity of the 20S proteasome have transformed the treatment of multiple B-cell malignancies. These agents have also been employed with success in the treatment of patients with autoimmune diseases and immune-mediated ...
Christopher J. Kirk +3 more
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Protein modification and maintenance systems as biomarkers of ageing [PDF]
, 2015 Changes in the abundance and post-translational modification of proteins and accumulation of some covalently modified proteins have been proposed to represent hallmarks of biological ageing.
Friguet, Bertrand +7 more
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