Results 41 to 50 of about 5,882 (203)

Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology [PDF]

Res Sq
Immunoproteasome induction is prominent in Alzheimers disease (AD), but whether it protects proteostasis or amplifies neuroinflammation remains unresolved.
Helen Y Figueroa, Mayank Kumar, Shan Jiang, Malavika Srikanth, Timothy Lantin, Steven M Wellman, Mu Yang, Daniella E Lorman, Avery M Runyan, Natura Myeku, Shrita Sarkar, Qi Wang, Eric Sydney   +12 more
europepmc   +2 more sources

The Immunoproteasome and Viral Infection: A Complex Regulator of Inflammation

Frontiers in Microbiology, 2015
During viral infection, proper regulation of immune responses is necessary to ensure successful viral clearance with minimal host tissue damage. Proteasomes play a crucial role in the generation of antigenic peptides for presentation on MHC class I ...
Mary Katherine McCarthy, Jason Brice Weinberg, Jason Brice Weinberg   +2 more
doaj   +1 more source

Pathogenic roles of immunoproteasomes in fibrosis. [PDF]

Essays Biochem
The 26S proteasome is a multi-subunit protease complex that degrades most eukaryotic cellular proteins. It not only regulates individual protein’s half-lives but also maintains proteome homeostasis and modulates immunological responses. During conditions involving large-scale proteome remodeling, such as fibrosis and cellular differentiation, the 26S ...
Kim S, Park SH, Lee MJ.
europepmc   +3 more sources

Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors

Molecules, 2021
The immunoproteasome is a multicatalytic protease that is predominantly expressed in cells of hematopoietic origin. Its elevated expression has been associated with autoimmune diseases, various types of cancer, and inflammatory diseases.
Eva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec, Izidor Sosič   +7 more
doaj   +1 more source

Role of Immunoproteasomes in Cross-Presentation [PDF]

The Journal of Immunology, 2006
Abstract The evidence that proteasomes are involved in the processing of cross-presented proteins is indirect and based on the in vitro use of proteasome inhibitors. It remains, therefore, unclear whether cross-presentation of MHC class I peptide epitopes can occur entirely within phagolysosomes or whether it requires proteasome ...
Palmowski, M, Gileadi, U, Salio, M, Gallimore, A, Millrain, M, James, E, Addey, C, Scott, D, Dyson, J, Simpson, E, Cerundolo, V   +10 more
openaire   +3 more sources

Association of immunoproteasomes with the endoplasmic reticulum [PDF]

Biochemical Journal, 2000
Proteasomes are complex multisubunit proteases which play a critical role in intracellular proteolysis. Immunoproteasomes, which contain three γ-interferon-inducible subunits, are a subset of proteasomes which have a specialized function in antigen processing for presentation by the MHC class I pathway.
Brooks, P., Murray, R. Z., Mason, G. G.F., Hendil, K. B., Rivett, A. J.   +4 more
openaire   +3 more sources

Blood Immunoproteasome Activity Is Regulated by Sex, Age and in Chronic Inflammatory Diseases: A First Population-Based Study

Cells, 2021
Dysfunction of the immunoproteasome has been implicated in cardiovascular and pulmonary diseases. Its potential as a biomarker for predicting disease stages, however, has not been investigated so far and population-based analyses on the impact of sex and
Ilona Elisabeth Kammerl, Claudia Flexeder, Stefan Karrasch, Barbara Thorand, Margit Heier, Annette Peters, Holger Schulz, Silke Meiners   +7 more
doaj   +1 more source

Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

, 2019
The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of Systemic Lupus Erythematosus. One potential mechanism of this clinical benefit is from the depletion of pathogenic immune cells (plasmablasts and plasmacytoid ...
Seth F. Harris (1503169), Martin Augustin (190894), Christine Everett, Steven T. Staben, Ena Ladi, Christine Everett (1638919), Malcolm P. Huestis (2001247), Seth F. Harris, Ena Ladi (7052597), Stefan Steinbacher, Michael Siu, Hans E. Purkey, Blake E. Daniels (4174042), Stefan Steinbacher (1981486), Hans E. Purkey (1346379), Craig E. Stivala (1861234), Rajita Pappu, Malcolm P. Huestis, Blake E. Daniels, Rajita Pappu (7052603), Matthew R. Durk, Craig E. Stivala, Steven T. Staben (1845742), Celine Eidenschenk (266709), Martin Augustin, Matthew R. Durk (7052600), Michael Blaesse (6191972), Celine Eidenschenk, Michael Siu (1503160), Michael Blaesse   +29 more
core   +3 more sources

PSMB9 codon 60 polymorphisms have no impact on the activity of the immunoproteasome catalytic subunit B1i expressed in multiple types of solid cancer. [PDF]

PLoS ONE, 2013
The proteasome is a key regulator of cellular protein homeostasis and is a clinically validated anticancer target. The immunoproteasome, a subtype of proteasome expressed mainly in hematopoietic cells, was initially recognized for its role in antigen ...
Ji Eun Park, Lin Ao, Zachary Miller, Kyungbo Kim, Ying Wu, Eun Ryoung Jang, Eun Young Lee, Kyung Bo Kim, Wooin Lee   +8 more
doaj   +1 more source

Inhibitors of the immunoproteasome: current status and future directions

, 2013
The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein homeostasis and regulating numerous cellular processes. The proteasome, a multi-protease complex, is the key component of the UPS and has been validated as a therapeutic ...
Lee, Wooin, Ao, Lin, Kim, Kyung Bo, Miller, Zachary   +3 more
core   +1 more source