Results 31 to 40 of about 253,705 (262)
Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes
Cell Reports, 2012 The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood.
Sang Mi Shim +5 more
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Cells, 2023 Hepatitis C virus (HCV) is constantly exposed to considerable oxidative stress, characterized by elevated levels of reactive oxygen species, including hydrogen peroxide (H2O2), during acute and chronic infection in the hepatocytes of patients.
Hyunyoung Yoon, Kyung Lib Jang
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The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]
, 2014 p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das +11 more
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The Proteasome Activator PA200/PSME4: An Emerging New Player in Health and Disease
Biomolecules, 2022 Proteasomes comprise a family of proteasomal complexes essential for maintaining protein homeostasis. Accordingly, proteasomes represent promising therapeutic targets in multiple human diseases.
Ayse Seda Yazgili +2 more
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Aptamer-Hytac Chimeras for Targeted Degradation of SARS-CoV-2 Spike-1
CellsThe development of novel tools to tackle viral processes has become a central focus in global health, during the COVID-19 pandemic. The spike protein is currently one of the main SARS-CoV-2 targets, owing to its key roles in infectivity and virion ...
Carme Fàbrega +7 more
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Inhibitory Effect of b-AP15 on the 20S Proteasome
Biomolecules, 2014 The 26S proteasome is a cellular proteolytic complex containing 19S regulatory particles and the 20S core proteasome. It was reported that the small molecule b-AP15 targets the proteasome by inhibiting deubiquitination of the 19S regulatory particles of
Li Huang, Katherine Jung, Chin Ho Chen
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Membranes, 2021 Proteasomes are multi-catalytic complexes with important roles in protein control. Their activity in stored red blood cells (RBCs) is affected by both storage time and the donor’s characteristics.
Alkmini T. Anastasiadi +9 more
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Biomolecules, 2021 Dienone compounds with a 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore have been widely reported to show tumor cell selectivity. These compounds target the ubiquitin-proteasome system (UPS), known to be essential for the viability of tumor cells.
Karthik Selvaraju +8 more
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Endocrine Resistance in Breast Cancer: The Role of Estrogen Receptor Stability
Cells, 2020 Therapy of hormone receptor positive breast cancer (BCa) generally targets estrogen receptor (ER) function and signaling by reducing estrogen production or by blocking its interaction with the ER. Despite good long-term responses, resistance to treatment
Sarah A. Jeffreys +8 more
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Protective Roles of Cytosolic and Plastidal Proteasomes on Abiotic Stress and Pathogen Invasion
Plants, 2020 Protein malfunction is typically caused by abiotic stressors. To ensure cell survival during conditions of stress, it is important for plant cells to maintain proteins in their respective functional conformation.
Md. Sarafat Ali, Kwang-Hyun Baek
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