Results 21 to 30 of about 248,818 (307)
The capture proteasome assay (CAPA) to evaluate subtype-specific proteasome inhibitors
Data in Brief, 2015 We recently developed a new assay to measure proteasome activity in vitro (CAPA for capture proteasome assay) [1], based on proteasome capture on an antibody-coated plate.
Nathalie Vigneron +2 more
doaj +1 more source
fang688/Proteasome-structure-analysis: Proteasome-structure-analysis v1.0
, 2023 Proteasome structure analysis package ...
fang688
core +1 more source
Pharmaceutics, 2023 Gold nanoparticles (AuNPs) are widely used in biomedicine due to their remarkable therapeutic applications. However, little is known about their cytotoxic effects on the ubiquitin proteasome system (UPS).
Bashiru Ibrahim +4 more
doaj +1 more source
Molecular Cell, 2011 Proteasomes degrade a multitude of protein substrates in the cytosol and nucleus, and thereby are essential for many aspects of cellular function. Because the proteolytic sites are sequestered in a closed barrel-shaped structure, activators are required to facilitate substrate access.
Stadtmueller, Beth M. +1 more
openaire +2 more sources
The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]
, 2013 The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Spooner, Robert A. +12 more
core +1 more source
luyinghms/Proteasome-FEL-model: Proteasome FEL model MATLAB v1.0
, 2023 Source code of proteasome FEL model (Nov ...
luyinghms
core +1 more source
Frontiers in Molecular Biosciences, 2019 The proteasome is a multi-catalytic molecular machine that plays a key role in the degradation of many cytoplasmic and nuclear proteins. The proteasome is essential and proteasome malfunction is associated with various disease pathologies.
Sabine Schipper-Krom +6 more
doaj +1 more source
Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster [PDF]
, 2004 The intracellular localization of the 26S proteasome in the different ovarian cell types of Drosophila melanogaster was studied by means of immunofluorescence staining and laser scanning microscopy, with the use of antibodies specific for regulatory ...
Andó, István +5 more
core +1 more source
Pharmaceutics, 2023 Chordomas account for approximately 1–4% of all malignant bone tumors and 20% of primary tumors of the spinal column. It is a rare disease, with an incidence estimated to be approximately 1 per 1,000,000 people.
Amrendra K. Ajay +14 more
doaj +1 more source
Cell Chemical Biology, 2017 While proteasome inhibitors are now well-established research tools and chemotherapeutics, proteasome activators are much less explored. In this issue of Cell Chemical Biology, in a study from the groups of Berkers and Ovaa (Leestemaker et al., 2017), a chemical screen was used to identify a p38 MAPK inhibitor as a proteasome activator.
Krahn, Jan +2 more
openaire +3 more sources