Results 11 to 20 of about 253,705 (262)

Polyamines directly promote antizyme-mediated degradation of ornithine decarboxylase by the proteasome

Microbial Cell, 2015
Ornithine decarboxylase (ODC), a ubiquitin-independent substrate of the proteasome, is a homodimeric protein with a rate-limiting function in polyamine biosynthesis.
R. Roshini Beenukumar, Daniela Gödderz, R. Palanimurugan, R. Jürgen Dohmen   +3 more
doaj   +2 more sources

Dss1 Is a 26S Proteasome Ubiquitin Receptor [PDF]

, 2014
The ubiquitin-proteasome system is the major pathway for protein degradation in eukaryotic cells. Proteins to be degraded are conjugated to ubiquitin chains that act as recognition signals for the 26S proteasome.
Hardwick, Kevin G., Hay, Ronald T., Larsen, Ida B., Kragelund, Birthe B., Tatham, Michael H, Rösner, Heike I, Kragelund, Birthe Brandt, Hay, Ronald T, Kragelund, Birthe B, Kriegenburg, Franziska, Tatham, Michael H., Rösner, Heike Ilona, Paraskevopoulos, Konstantinos, Brandstrup, Rikke, Larsen, Ida B, Medina, Bethan; id_orcid, Hartmann-Petersen, Rasmus, Gordon, Colin, Rösner, Heike I., Hardwick, Kevin G, Medina, Bethan   +20 more
core   +1 more source

Cardiovascular toxicity of proteasome inhibitors in multiple myeloma therapy

, 2022
The treatment for multiple myeloma has advanced significantly over the past few decades. Proteasome inhibitors have become the cornerstone of the treatment of multiple myeloma.
Huang, Shan, Tse, Gary, Xie, Bingxin, Liu, Tong, Zhang, Nan, Zheng, Yi, Liu, Zhiqiang   +6 more
core   +2 more sources

Fluorescence-based proteasome activity profiling [PDF]

, 2011
With the proteasome emerging as a therapeutic target for cancer treatment, accurate tools for monitoring proteasome (inhibitor) activity are in demand.
Jong, A., Rodenko, B., Berkers, C.R., Schuurman, K.G., Ovaa, H., Boris Rodenko, Annemieke de Jong, Celia R. Berkers, Karianne G. Schuurman, Huib Ovaa   +9 more
core   +1 more source

Assembly of the Drosophila 26 S proteasome is accompanied by extensive subunit rearrangements [PDF]

, 2002
The subunit contacts in the regulatory complex of the Drosophila 26 S proteasome were studied through the cross-linking of closely spaced subunits of the complex, and analysis of the cross-linking pattern in an immunoblot assay with the use of subunit ...
Kapelari, Barbara, Barbara KAPELARI, Sümegi, Máté, Baumeister, Wolfgang, Hölzl, Harald, Éva KURUCZ, Máté SÜMEGI, István ANDÓ, Harald HÖLZL, Andó, István, Kurucz, Éva, Udvardy, Andor, Andor UDVARDY, Wolfgang BAUMEISTER   +13 more
core   +2 more sources

Functional analysis of proteasome-associated ubiquitin ligases in plants [PDF]

, 2022
Degradation of intracellular proteins by the ubiquitin-proteasome system (UPS) is a sophisticated mechanism that begins with anchoring ubiquitin molecules to a substrate and ends with proteasome-dependent proteolysis.
Wang, Zhishuo
core   +1 more source

Interplay between RNA Viruses and Promyelocytic Leukemia Nuclear Bodies

Veterinary Sciences, 2021
Promyelocytic leukemia nuclear bodies (PML NBs) are nuclear membrane-less sub structures that play a critical role in diverse cellular pathways including cell proliferation, DNA damage, apoptosis, transcriptional regulation, stem cell renewal ...
Sabari Nath Neerukonda
doaj   +1 more source

fang688/Proteasome-structure-analysis: Proteasome-structure-analysis v1.0

, 2023
Proteasome structure analysis package ...
fang688
core   +1 more source

Proteasome as a Molecular Target of Microcystin-LR

Toxins, 2015
Proteasome degrades proteins in eukaryotic cells. As such, the proteasome is crucial in cell cycle and function. This study proved that microcystin-LR (MC-LR), which is a toxic by-product of algal bloom, can target cellular proteasome and selectively ...
Zhu Zhu, Li Zhang, Guoqing Shi
doaj   +1 more source

luyinghms/Proteasome-FEL-model: Proteasome FEL model MATLAB v1.0

, 2023
Source code of proteasome FEL model (Nov ...
luyinghms
core   +1 more source