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The mitochondrion as Janus Bifrons

Biochemistry (Moscow), 2007
The signaling function of mitochondria is considered with a special emphasis on their role in the regulation of redox status of the cell, possibly determining a number of pathologies including cancer and aging. The review summarizes the transport role of mitochondria in energy supply to all cellular compartments (mitochondria as an electric cable in ...
D B, Zorov   +7 more
openaire   +2 more sources

Systems biology of the mitochondrion

American Journal of Physiology-Cell Physiology, 2006
The promise of the current era of biological research is to understand the integrated function of biological systems in order to predict and rationally manipulate their behavior, with the ultimate aim of improving human health.
Daniel A, Beard, Marko, Vendelin
openaire   +2 more sources

NUCLEOPROTEIN SYNTHESIS IN THE MITOCHONDRION

Canadian Journal of Genetics and Cytology, 1969
Lipolated (fat-filled) mitochondria in Saccharomyces have been observed both by light-microscopy and by electron-microscopy. Previous workers have shown, by ultraviolet-microscopy and by fat stains, using the light-microscope, that the lipolated mitochondria contain both lipids and ribonucleotides.
C C, Lindegren, J M, Zink
openaire   +2 more sources

Redox Pathways of the Mitochondrion

Antioxidants & Redox Signaling, 2006
The mitochondrion houses a variety of redox pathways, utilized for protection from oxidative damage and assembly of the organelle. The glutathione/glutaredoxin and thioredoxin systems function in the mitochondrial matrix. The intermembrane space is protected from oxidative damage via superoxide dismutase and glutathione.
Carla M, Koehler   +2 more
openaire   +2 more sources

Taurine and the Mitochondrion

2023
Several studies have evaluated the subcellular compartmentalization of taurine (TAU) and its cellular and molecular mechanisms of action. Meanwhile, it has been found that TAU is largely uptaken by mitochondria. TAU could improve mitochondrial function by incorporating it into the basic mitochondrial structures and protein synthesis (e.g., mainly ...
Reza Heidari, M. Mehdi Ommati
openaire   +1 more source

Mitochondrion as a Multifunctional Organelle

Nature, 1971
Mitochondria are the site of much more than electron transport and oxidative phosphorylation. This should not be forgotten if mitochondrial function is to be understood.
openaire   +2 more sources

The Mitochondrion

New England Journal of Medicine, 1967
D F, Tapley, D V, Kimberg, J L, Buchanan
openaire   +3 more sources

The Mitochondrion Updated

Science, 1986
M D, Lane, P L, Pedersen, A S, Mildvan
openaire   +2 more sources

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