Experimental analyses of the proteins found in the mitochondria of yeast, humans and Arabidopsis have confirmed some expectations but given some surprises and some insights into the evolutionary origins of mitochondrial proteins.
Heazlewood, JL+3 more
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FAIRE-seq data analysis of Chlamydomonas reinhardtii under carbon deprivation [PDF]
For the genome-wide identification of nucleosome depleted regions under carbon deprivation, we analyze an available set of data from an assay of formaldehyde-assisted isolation of regulatory elements followed by sequencing (FAIRE-seq).
Bernd Mü+3 more
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Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC [PDF]
Microsporidia are obligate intracellular parasites with extremely reduced genomes and a dependence on host-derived ATP. The microsporidium Encephalitozoon cuniculi proliferates within a membranous vacuole and we investigated how the ATP supply is ...
Bhella, David+3 more
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Evolution and disease converge in the mitochondrion
Mitochondrial DNA (mtDNA) mutations are long known to cause diseases but also underlie tremendous population divergence in humans. It was assumed that the two types of mutations differ in one major trait: functionality. However, evidence from disease association studies, cell culture and animal models support the functionality of common mtDNA genetic ...
Dan Mishmar, Ilia Zhidkov
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On the InterAktion between Hexokinase and the Mitochondrion [PDF]
The protein kinase Akt is now well recognized as a potent inhibitor of apoptosis. Work published by Majewski et al. in the December 3rd issue of Molecular Cell indicates that a major pathway by which Akt suppresses cell death is by stimulating the translocation of hexokinase to the mitochondrion.
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Cellular Evolution: What's in a Mitochondrion? [PDF]
Mitochondria and their relatives constitute a wide range of organelles, only some of which function in aerobic respiration. Mitochondrial remnants from different anaerobic lineages show a striking degree of functional convergence.
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Protein translocation pathways of the mitochondrion [PDF]
The biogenesis of mitochondria depends on the coordinated import of precursor proteins from the cytosol coupled with the export of mitochondrially coded proteins from the matrix to the inner membrane. The mitochondria contain an elaborate network of protein translocases in the outer and inner membrane along with a battery of chaperones and processing ...
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Localization of riboproteins in a trypanosomatid mitochondrion
There is growing evidence in support of mitochondrial translation in trypanosomes but mitoribosomes have never been characterized or localized in these parasites. On RNA–protein blots we identified several proteins from the trypanosomatid Crithidia fasciculata which bound the parasite's 12S and 9S mitochondrial ribosomal RNAs. Two of these proteins had
Vladimir Baranov, Ivor Tittawella
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Expression of the Mitochondrial Genome in HeLa Cells. XV. Effect of Inhibition of Mitochondrial Protein Synthesis on Mitochondrial Formation [PDF]
The effect of selective inhibition of mitochondrial protein synthesis by chloramphenicol at 40 or 200 µg/ml on the formation of mitochondria in HeLa cells was investigated.
Attardi, Giuseppe, Storrie, Brian
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COMPARTMENTATION OF THE MITOCHONDRION [PDF]
David E. Green, Gerald Brierley
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