Results 51 to 60 of about 226,740 (385)

Lead and the mitochondrion [PDF]

Postgraduate Medical Journal, 1975
Summary In studies on the distribution of lead in rats given drinking water containing lead acetate at concentrations: 0, 100, 500, 1000 and 5000 μgPb/l for one year, no change was observed in the organ distribution of lead, or in the subcellular distribution of lead in the organelles in the heart. The mitochondrial enzyme,
openaire   +3 more sources

Acute Succinate Administration Increases Oxidative Phosphorylation and Skeletal Muscle Explosive Strength via SUCNR1

Frontiers in Veterinary Science, 2022
Endurance training and explosive strength training, with different contraction protein and energy metabolism adaptation in skeletal muscle, are both beneficial for physical function and quality of life.
Guli Xu, Yexian Yuan, Pei Luo, Jinping Yang, Jingjing Zhou, Canjun Zhu, Qingyan Jiang, Gang Shu   +7 more
doaj   +1 more source

Mitochondrial behaviour throughout the lytic cycle of Toxoplasma gondii [PDF]

, 2017
Mitochondria distribution in cells controls cellular physiology in health and disease. Here we describe the mitochondrial morphology and positioning found in the different stages of the lytic cycle of the eukaryotic single-cell parasite Toxoplasma gondii.
Lemgruber, Leandro, Ovciarikova, Jana, Sheiner, Lilach, Stilger, Krista L., Sullivan, William J.   +4 more
core   +2 more sources

Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

Cells, 2021
Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska, Anna Wieczorek, Artur Jóźwik, Anna Walaszczyk, Karol Jelonek, Grażyna Szczukiewicz-Markowska, Olaf K. Horbańczuk, Monika Pietrowska, Piotr Widłak, Dorota Gabryś   +9 more
doaj   +1 more source

BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei [PDF]

, 2014
While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle.
Barrett, Michael P., Billker, Oliver, Creek, Darren J., Limenitakis, Julien, Macrae, James I., McConville, Malcolm J., Modrzynska, Katarzyna K., Oppenheim, Rebecca D., Pino, Paco, Polonais, Valerie, Seeber, Frank, Soldati-Favre, Dominique   +11 more
core   +1 more source

Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent

EMBO Journal, 2019
The mitochondrial membrane potential (ΔΨm) is the main driver of oxidative phosphorylation (OXPHOS). The inner mitochondrial membrane (IMM), consisting of cristae and inner boundary membranes (IBM), is considered to carry a uniform ΔΨm.
Dane M. Wolf, Mayuko Segawa, Arun Kumar Kondadi, Ruchika Anand, Sean T. Bailey, A. Reichert, A. M. van der Bliek, D. Shackelford, M. Liesa, O. Shirihai   +9 more
semanticscholar   +1 more source

Disturbance of Mitochondrial Dynamics and Mitochondrial Therapies in Atherosclerosis

Life, 2021
Mitochondrial dysfunction is associated with a wide range of chronic human disorders, including atherosclerosis and diabetes mellitus. Mitochondria are dynamic organelles that undergo constant turnover in living cells.
Alexander M. Markin, Viktoria A. Khotina, Xenia G. Zabudskaya, Anastasia I. Bogatyreva, Antonina V. Starodubova, Ekaterina Ivanova, Nikita G. Nikiforov, Alexander N. Orekhov   +7 more
doaj   +1 more source

Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g [PDF]

, 2009
Crista junctions (CJs) are important for mitochondrial organization and function, but the molecular basis of their formation and architecture is obscure.
Al-Amoudi, Allen, Andreas S. Reichert, Andreja Vasiljev-Neumeyer, Arnold, Bornhövd, Buzhynskyy, Christian Körner, Cipolat, Claros, Cyrklaff, Daems, DiMauro, Dubochet, Dudkina, Dudkina, Emaus, Fawcett, Frank Vogel, Frey, Frey, Frezza, Ghaemmaghami, Gilkerson, Hegerl, Herlan, Herlan, Icho, John, Mannella, Mannella, Mannella, Mannella, Marek Cyrklaff, Meeusen, Meier, Merkwirth, Merkwirth, Minauro-Sanmiguel, Mokranjac, Munn, Nadine Mendl, Nicastro, Nickell, Odgren, Olichon, Paumard, Perkins, Perkins, Perkins, Pon, Puig, Ravi Jagasia, Regina Rabl, Renken, Roland Scholz, Rowley, Schagger, Scorrano, Sherman, Sirrenberg, Strauss, Taylor, Thomas Keil, Tokuyasu, Velours, Vincent Soubannier, Vogel, Wach, Wallace, Walter Neupert, Werner, Westermann, Wittig, Wolfgang Baumeister, Wong, Wurm, Zick   +77 more
core   +2 more sources

Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single-Mitochondrion Sequencing

Cell Reports, 2017
Summary: A number of mitochondrial diseases arise from single-nucleotide variant (SNV) accumulation in multiple mitochondria. Here, we present a method for identification of variants present at the single-mitochondrion level in individual mouse and human
Jacqueline Morris, Young-Ji Na, Hua Zhu, Jae-Hee Lee, Hoa Giang, Alexandra V. Ulyanova, Gordon H. Baltuch, Steven Brem, H. Isaac Chen, David K. Kung, Timothy H. Lucas, Donald M. O’Rourke, John A. Wolf, M. Sean Grady, Jai-Yoon Sul, Junhyong Kim, James Eberwine   +16 more
doaj   +1 more source

Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always [PDF]

, 2017
Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle.
Carelli, Valerio, Georg, Birgitte, Ghelli, Anna, Giordano, Carla, Hannibal, Jens, La Morgia, Chiara, Ross Cisneros, Fred N., Sadun, Alfredo A.   +7 more
core   +1 more source