Results 51 to 60 of about 367,263 (290)

Myosin A and F-Actin play a critical role in mitochondrial dynamics and inheritance in Toxoplasma gondii.

PLoS Pathogens
The single mitochondrion of the obligate intracellular parasite Toxoplasma gondii is highly dynamic. Toxoplasma's mitochondrion changes morphology as the parasite moves from the intracellular to the extracellular environment and during division ...
Rodolpho Ornitz Oliveira Souza, Chunlin Yang, Gustavo Arrizabalaga   +2 more
doaj   +1 more source

Dietary Supplementation With High Fiber Alleviates Oxidative Stress and Inflammatory Responses Caused by Severe Sepsis in Mice Without Altering Microbiome Diversity

Frontiers in Physiology, 2019
In this study, we demonstrated the effects of a high-fiber diet on intestinal lesions, oxidative stress and systemic inflammation in a murine model of endotoxemia.
Yuanyuan Zhang, Aili Dong, Keliang Xie, Yonghao Yu   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Mitochondrion in a cone photoreceptor pedicle: movie

, 2016
Presents movie showing the three-dimensional details of cone pedicle mitochondria generated using electron tomography. Pedicles averaged five medium-sized mitochondria clustered far from the active zones.
Perkins, Guy A., Ellisman, Mark H., Poquiz, Patrick H., Fox, Donald A.   +3 more
core   +2 more sources

Cell Biology of the Mitochondrion [PDF]

Genetics, 2017
AbstractMitochondria are best known for harboring pathways involved in ATP synthesis through the tricarboxylic acid cycle and oxidative phosphorylation. Major advances in understanding these roles were made with Caenorhabditiselegans mutants affecting key components of the metabolic pathways.
van der Bliek, Alexander M, Sedensky, Margaret M, Morgan, Phil G   +2 more
openaire   +4 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

AMPK regulates ARF1 localization to membrane contact sites to facilitate fatty acid transfer between lipid droplets and mitochondria

Cell Death and Disease
Lipid droplet (LD) -mitochondrion contacts play a crucial role in regulating energy metabolism and fatty acid oxidation in skeletal muscle cells. However, the proteins that regulate these interactions remain poorly understood.
Lupeng Chen, Yue Liu, Junzhi Zhang, Tongxing Song, Jian Wu, Zhuqing Ren   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mitochondrion in a cone photoreceptor pedicle: movie

, 2011
Presents movie showing the three-dimensional details of cone pedicle mitochondria generated using electron tomography. Pedicles averaged five medium-sized mitochondria clustered far from the active zones.
Perkins, Guy A., Ellisman, Mark H., Poquiz, Patrick H., Fox, Donald A.   +3 more
core   +2 more sources

Mitochondrion in a rod photoreceptor spherule: movie

, 2011
Presentes a movie showing the three-dimensional details of rod spherule mitochondria generated using electron tomography. Spherules have one large ovoid mitochondrion located near the active zone.
Perkins, Guy A., Ellisman, Mark H., Poquiz, Patrick H., Fox, Donald A.   +3 more
core   +1 more source