Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]
PLoS ONE, 2013 Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and bioavailability. Malvidin
Eszter Bognar +7 more
doaj +15 more sources
Rice mitogen activated protein kinase kinase and mitogen activated protein kinase interaction network revealed by in-silico docking and yeast two-hybrid approaches. [PDF]
PLoS ONE, 2013 Protein-protein interaction is one of the crucial ways to decipher the functions of proteins and to understand their role in complex pathways at cellular level.
Dhammaprakash Pandhari Wankhede +3 more
doaj +1 more source
Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]
PLoS ONE, 2008 Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay +9 more
doaj +1 more source
Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood
Acta Dermato-Venereologica, 2022 Pyogenic granuloma is one of the most common vascular tumours. The cause of pyogenic granuloma was previously thought to be an inflammatory reaction with consecutive stimulation of endothelial cell proliferation.
Katharina Strobel +6 more
doaj +1 more source
Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. [PDF]
PLoS ONE, 2017 The ovary is the main regulator of female fertility. Granulosa cell dysfunction may be involved in various reproductive endocrine disorders. Here we investigated the effect of insulin resistance on the metabolism and function of ovarian granulosa cells ...
Linghui Kong +8 more
doaj +1 more source
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. [PDF]
, 2017 c-Jun N-terminal kinase (JNK) is a member of the mitogen-activated protein kinase family and controls various physiological processes including apoptosis. A specific upstream activator of JNKs is the mitogen-activated protein kinase kinase 7 (MKK7).
Deki-Arima, Norie +15 more
core +2 more sources
Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks
Frontiers in Plant Science, 2020 Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan +3 more
doaj +1 more source
Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. [PDF]
PLoS ONE, 2009 Mechanical ventilation, a fundamental therapy for acute lung injury, worsens pulmonary vascular permeability by exacting mechanical stress on various components of the respiratory system causing ventilator associated lung injury.
Mahendra Damarla +14 more
doaj +1 more source
Mitogen-activated protein kinase kinase 1 (MKK1) is negatively regulated by threonine phosphorylation [PDF]
, 1994 Mitogen-activated protein kinase kinase 1 (MKK1), a dual-specificity tyrosine/threonine protein kinase, has been shown to be phosphorylated and activated by the raf oncogene product as part of the mitogen-activated protein kinase cascade.
Rossomando, A. J. +3 more
core +1 more source
Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module [PDF]
, 1994 We present genetic evidence for complex formation of STE5 and the STE11, STE7, and FUS3 protein kinases, the pheromone-responsive mitogen-activated protein kinase module of Saccharomyces cerevisiae.
Marcus, S. +3 more
core +1 more source