Results 1 to 10 of about 4,675,421 (262)

Rice mitogen activated protein kinase kinase and mitogen activated protein kinase interaction network revealed by in-silico docking and yeast two-hybrid approaches. [PDF]

PLoS ONE, 2013
Protein-protein interaction is one of the crucial ways to decipher the functions of proteins and to understand their role in complex pathways at cellular level.
Dhammaprakash Pandhari Wankhede, Mohit Misra, Pallavi Singh, Alok Krishna Sinha   +3 more
doaj   +1 more source

Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. [PDF]

PLoS ONE, 2008
Mechanical ventilation causes ventilator-induced lung injury in animals and humans. Mitogen-activated protein kinases have been implicated in ventilator-induced lung injury though their functional significance remains incomplete. We characterize the role
Tamás Dolinay, Wei Wu, Naftali Kaminski, Emeka Ifedigbo, A Murat Kaynar, Mária Szilasi, Simon C Watkins, Stefan W Ryter, Alexander Hoetzel, Augustine M K Choi   +9 more
doaj   +1 more source

Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. [PDF]

PLoS ONE, 2013
Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and bioavailability. Malvidin
Eszter Bognar, Zsolt Sarszegi, Aliz Szabo, Balazs Debreceni, Nikoletta Kalman, Zsuzsanna Tucsek, Balazs Sumegi, Ferenc Gallyas   +7 more
doaj   +1 more source

Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood

Acta Dermato-Venereologica, 2022
Pyogenic granuloma is one of the most common vascular tumours. The cause of pyogenic granuloma was previously thought to be an inflammatory reaction with consecutive stimulation of endothelial cell proliferation.
Katharina Strobel, Katja Maurus, Henning Hamm, Sabine Roth, Matthias Goebeler, Andreas Rosenwald, Marion Wobser   +6 more
doaj   +1 more source

Insulin resistance enhances the mitogen-activated protein kinase signaling pathway in ovarian granulosa cells. [PDF]

PLoS ONE, 2017
The ovary is the main regulator of female fertility. Granulosa cell dysfunction may be involved in various reproductive endocrine disorders. Here we investigated the effect of insulin resistance on the metabolism and function of ovarian granulosa cells ...
Linghui Kong, Qien Wang, Jiewen Jin, Zou Xiang, Taoyu Chen, Shanmei Shen, Hongwei Wang, Qian Gao, Yong Wang   +8 more
doaj   +1 more source

Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks

Frontiers in Plant Science, 2020
Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan, Lixia Pan, Ive De Smet, Ive De Smet   +3 more
doaj   +1 more source

Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury. [PDF]

PLoS ONE, 2009
Mechanical ventilation, a fundamental therapy for acute lung injury, worsens pulmonary vascular permeability by exacting mechanical stress on various components of the respiratory system causing ventilator associated lung injury.
Mahendra Damarla, Emile Hasan, Adel Boueiz, Anne Le, Hyun Hae Pae, Calypso Montouchet, Todd Kolb, Tiffany Simms, Allen Myers, Usamah S Kayyali, Matthias Gaestel, Xinqi Peng, Sekhar P Reddy, Rachel Damico, Paul M Hassoun   +14 more
doaj   +1 more source

Mitogen-Activated Protein Kinase Pathway in Amyotrophic Lateral Sclerosis

Biomedicines, 2021
Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease. Multiple genetic and non-genetic risk factors are associated with disease pathogenesis, and several cellular processes, including protein homeostasis, RNA metabolism, vesicle ...
TG Sahana, Ke Zhang
doaj   +1 more source

PREDICTION OF 3D STRUCTURE OF MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 USING ALPHAFOLD 2 AND SIMULATION OF ITS INTERACTION WITH MITOGEN-ACTIVATED PROTEIN KINASE 6 IN ARABIDOPSIS THALIANA [PDF]

Journal of Plant Development
Arabidopsis thaliana mitogen-activated protein kinase (MPK or MAPK) signaling network plays significant roles in various cellular processes. The three-dimensional structure of mitogen-activated protein kinase kinase 2 (MKK2), an upstream kinase in the ...
Sameer KHAN, Tim XING
doaj   +1 more source

Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinase pathways

Journal of Ginseng Research, 2016
Background: Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, and endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary ...
Na Qin, Wei Yang, Dongxu Feng, Xinwen Wang, Muyao Qi, Tianxin Du, Hongzhi Sun, Shufang Wu   +7 more
doaj   +1 more source