Results 111 to 120 of about 4,675,421 (262)

In-silico genome wide analysis of Mitogen activated protein kinase kinase kinase gene family in C. sinensis

PLoS ONE, 2021
Mitogen activated protein kinase kinase kinase (MAPKKK) form the upstream component of MAPK cascade. It is well characterized in several plants such as Arabidopsis and rice however the knowledge about MAPKKKs in tea plant is largely unknown.
Abhirup Paul, Anurag P. Srivastava, Shreya Subrahmanya, Guoxin Shen, Neelam Mishra   +4 more
doaj  

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Supplementary Fig. S5 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Fig.
Eric Kort (14885115), Kyle Furge (259409), Yan Ding (39795), Rick V. Hay (15038574), Elissa A. Boguslawski (3289665), Bree D. Berghuis (15038565), James H. Resau (3160386), Kim Hardy (15038571), Arthur E. Frankel (14885535), Nicholas S. Duesbery (14885124), John J. Young (15038568), Zhongfa Zhang (270814)   +11 more
core   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy

JACC: Basic to Translational Science
Summary: There is an unmet medical need to treat patients with severe hypertrophic cardiomyopathy leading to heart failure and death in children carrying pathogenic activating variants in the RAS/mitogen-activated protein kinase pathway.
Cordula M. Wolf, MD, Martin Zenker, MD, Olga Boleti, MD, Gabrielle Norrish, MD, Mark Russell, MD, Joshua K. Meisner, MD, PhD, David M. Peng, MD, Terence Prendiville, MBDchBAO, MD, Jake Kleinmahon, MD, Paul F. Kantor, MBBCh, Danielle Gottlieb Sen, MS, MD, MPH, Derek G. Human, BMBCh, Peter Ewert, MD, Marcus Krueger, MD, Daniela Reber, MD, Birgit Donner, MD, Christopher Hart, MD, Irena Odri Komazec, MD, PhD, Stefan Rupp, MD, Andreas Hahn, MD, Anja Hanser, MD, Michael Hofbeck, MD, Jos M.T. Draaisma, MD, Floris E.A. Udink ten Cate, MD, Alessandro Mussa, MD, PhD, Giovanni B. Ferrero, MD, PhD, Laurence Vaujois, MD, Marie-Josée Raboisson, MD, Marie-Ange Delrue, MD, Christopher Marquis, PhD, MD, Yves Théoret, PhD, MD, Soujanya Bogarapu, MD, Adrian Dancea, MD, Mette Moller Handrup, PhD, Mariska Kemna, MD, Tiina Ojala, MD, PhD, Niti Dham, MD, Frank Dicke, MD, Tim Friede, PhD, Juan Pablo Kaski, MD(Res), Bruce D. Gelb, MD, Gregor Andelfinger, MD   +41 more
doaj   +1 more source

Supplementary Fig. S4 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Fig.
Eric Kort (14885115), Kyle Furge (259409), Yan Ding (39795), Rick V. Hay (15038574), Elissa A. Boguslawski (3289665), Bree D. Berghuis (15038565), James H. Resau (3160386), Kim Hardy (15038571), Arthur E. Frankel (14885535), Nicholas S. Duesbery (14885124), John J. Young (15038568), Zhongfa Zhang (270814)   +11 more
core   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Supplementary Fig. S6 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Fig.
Eric Kort (14885115), Kyle Furge (259409), Yan Ding (39795), Rick V. Hay (15038574), Elissa A. Boguslawski (3289665), Bree D. Berghuis (15038565), James H. Resau (3160386), Kim Hardy (15038571), Arthur E. Frankel (14885535), Nicholas S. Duesbery (14885124), John J. Young (15038568), Zhongfa Zhang (270814)   +11 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source