Mitogen-activated protein kinase

Results 121 to 130 of about 4,675,421 (262)

Evaluation of 2-(4-Chlorophenyl)-4-(4-fluorophenyl)-5-pyridin-4-yl-1,2-dihydropyrazol-3-one as a p38 MAPK inhibitor in MCF-7 and MDA-MB-231 breast cancer cell lines

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Breast cancer is a diverse disease with high mortality rates, often due to metastasis. Breast cancer subtypes vary by the expression of progesterone receptor, human epidermal growth factor receptor 2, and estrogen receptor.
Mustafa Abdul Jabbar a Qader +3 more
doaj +1 more source

Supplementary Table S1 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Table S1 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of ...
Eric Kort (14885115) +11 more
core +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie +24 more
wiley +1 more source

Supplementary Figure Legends from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Figure Legends from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of ...
Eric Kort (14885115) +11 more
core +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu +13 more
wiley +1 more source

Supplementary Fig. S1 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Fig.
Eric Kort (14885115) +11 more
core +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu +5 more
wiley +1 more source

Supplementary Fig. S3 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Fig.
Eric Kort (14885115) +11 more
core +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin +13 more
wiley +1 more source

Supplementary Fig. S2 from Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

, 2008
Supplementary Fig.
Eric Kort (14885115) +11 more
core +1 more source

medicine