Empowering AlphaFold2 for protein conformation selective drug discovery with AlphaFold2-RAVE [PDF]
Small molecule drug design hinges on obtaining co-crystallized ligand-protein structures. Despite AlphaFold2's strides in protein native structure prediction, its focus on apo structures overlooks ligands and associated holo structures. Moreover, designing selective drugs often benefits from the targeting of diverse metastable conformations. Therefore,
arxiv +1 more source
Estimation of kinetic rates of MAP kinase activation from experimental data [PDF]
, 2009 Mathematical model is an important tool in systems biology to study the dynamics of biological systems inside the cell. One of the significant challenges in systems biology is the lack of kinetic rates that should be measured in experiments or estimated ...
Tian, T.
core +1 more source
Chemotherapy‐Mediated Induction of PD‐L1 via SEI1 Facilitates Myeloma Immune Evasion
Advanced Science, EarlyView.Chemotherapy induces DNA damage, activating cyclic guanosine monophosphate (GMP)‐adenosine monophosphate (AMP) synthase (cGAS)/stimulator of interferon genes (STING), which phosphorylates interferon regulatory factor 7 (IRF7) to drive SERTA‐containing domain 1 (SEI1) transcription.
Rui Chen +9 more
wiley +1 more source
BJUI Compass, Volume 4, Issue 1, Page 44-58, January 2023., 2023 Abstract Metformin, the first line pharmacotherapy for type 2 diabetes has demonstrated favourable effects in prostate cancer (PCa) across a range of studies evaluating PCa patient outcomes amongst metformin users. However, a lack of rigorously conducted prospective studies has stalled clinical use in this setting.
Nan Fang Wang +3 more
wiley +1 more source
Expressed in the yeast Saccharomyces cerevisiae, human ERK5 is a client of the Hsp90 chaperone that complements loss of the Slt2p (Mpk1p) cell integrity stress-activated protein kinase [PDF]
, 2006 ERK5 is a mitogen-activated protein (MAP) kinase regulated in human cells by diverse mitogens and stresses but also suspected of mediating the effects of a number of oncogenes.
King, Victoria +7 more
core +2 more sources
Mitogen-Activated Protein Kinases and Mitogen-Activated Protein Kinase Phosphatases in Regenerative Myogenesis and Muscular Dystrophy [PDF]
, 2012 The mitogen-activated protein kinase (MAPK) signal transduction pathway is required to promote skeletal myogenesis and maintain skeletal muscle function. Although it has been long appreciated that the MAPK pathway plays a critical role in skeletal myogenesis it is still unclear as to whether the MAPKs are involved in the development of skeletal muscle ...
Anton M. Bennett, Hao Shi
openaire +3 more sources
Biomolecules, 2019 Flumequine is a well-known second generation quinolone antibiotic that induces phototoxicity. However, the effect of flumequine on skin melanogenesis is unclear.
Wisurumuni Arachchilage Hasitha Maduranga Karunarathne +6 more
doaj +1 more source
Advanced Science, EarlyView.This review explores the challenges of treating bone and cartilage defects, emphasizing the role of endogenous electric fields in bone and cartilage regeneration. It highlights recent advancements in electroactive biomaterials, including nanogenerators, piezoelectric materials, triboelectric scaffold, and zwitterionic hydrogels.
Yubin Yao +4 more
wiley +1 more source
Gene amplifications associated with the development of hormone- resistant prostate cancer [PDF]
, 2003 Purpose: Hormone resistance remains a significant clinical problem in prostate cancer with few therapeutic options. Research into mechanisms of hormone resistance is essential.
Bartlett, J.M.S. +3 more
core
Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection. [PDF]
, 2015 BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens.
Aguirre, Alejandro +13 more
core +1 more source