Results 221 to 230 of about 4,675,421 (262)

Toll‐Like Receptors in the Mechanism of Hexabromocyclododecane‐Induced Production of Pro‐Inflammatory Cytokines

Journal of Applied Toxicology, EarlyView.
ABSTRACT Hexabromocyclododecane (HBCD), a brominated flame retardant, has raised increasing health concerns due to its bioaccumulation in human tissues and its ability to induce proinflammatory cytokines. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) are major mediators of inflammation, and their chronic elevation ...
Wenjun Zhu, Aleshia Seaton‐Terry, Brian Townsend, Zinia Hunter, April Falconer‐Turner, Syeda Raika Shahid, Margaret Whalen   +6 more
wiley   +1 more source

Therapy-Associated Vitiligo: Hypopigmentation Secondary to Programmed Cell Death Protein 1 Inhibitors, Interferon Alfa-2b, Cytotoxic T-Lymphocyte-Associated Protein 4 Inhibitors, and B-Raf/Mitogen-Activated Protein Kinase Kinase Inhibitors. [PDF]

Cureus
Verma KK, Reddy S, Beckham C, Nguyen KT, Raman J, Olagbenro M, Pirtle FA, Tarbox M, Posligua A, Leachman SA, Desai S.   +10 more
europepmc   +1 more source

Concordance Study on Molecular Detection of Thyroid Nodules by Ultrasound Guided Fine Needle Aspiration

Journal of Clinical Laboratory Analysis, EarlyView.
This prospective study evaluated the performance of DNA and RNA next‐generation sequencing (NGS) using matched fine‐needle aspiration (FNA) and surgical tissue samples from an analysis cohort of 76 patients. ABSTRACT Background Fine needle aspiration (FNA) constitutes the primary preoperative evaluation for thyroid nodules.
Su Meng, Jianxiong Sun, Changliang Zhang, Zhixue Yang, Jinrong Wei, Si Chen, Yanan Li, Xiaoxiao Dai, Guoqin Jiang   +8 more
wiley   +1 more source

Dual-specificity mitogen-activated protein kinase kinases can use ADP to phosphorylate MAP kinases invitro. [PDF]

J Biol Chem
Juyoux P, von Velsen J, Pellegrini E, Bowler MW.   +3 more
europepmc   +1 more source

Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: A systematic review and meta‐analysis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are characterized by progressive neuronal loss driven by oxidative stress and inflammation. Quercetin, a dietary flavonoid with established antioxidant and anti‐inflammatory properties, has emerged as a potential neuroprotective agent.
In Ho Cho, Hendra Mahakam Putra, Cheol Woon Jung, Gyu Hwan Hyun, Hwan‐Hee Jang, In Guk Hwang, Sung Won Kwon   +6 more
wiley   +1 more source

Statement of Retraction: Alkannin reverses lipopolysaccharides-induced inflammatory responses by suppressing mitogen-activated protein kinase and nuclear factor kappa-B signalling. [PDF]

Bioengineered
europepmc   +1 more source

Jingui Shenqi pill ( ) treats cardiorenal syndrome by inhibiting mitogen-activated protein kinase signaling pathway and reducing inflammatory response. [PDF]

J Tradit Chin Med
Shuyan H, Xinyue D, Hui Z, Zongjun L, Yuling L, Lina X.   +5 more
europepmc   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells. [PDF]

Cancer Med
Wang X, Xu P, Luan S, Jiao Y, Gao Y, Zhao C, Fu P.   +6 more
europepmc   +1 more source

Cutaneous Rosai‐Dorfman Disease With MAP2K1 Mutation Treated With Encorafenib and Binimetinib

JEADV Clinical Practice, EarlyView.
ABSTRACT Rosai‐Dorfman disease (RDD) is a rare histiocytic disorder with unifocal to multisystemic involvement. Activating mutations in the MAPK/ERK pathway can occur in up to 50% of RDD cases. We report a case of cutaneous RDD (C‐RDD) with facial and truncal lesions harboring an activating MAP2K1 (MEK1) mutation that showed a complete response to a ...
Melike Ak, Reinhard Dummer, Egle Ramelyte   +2 more
wiley   +1 more source