Results 211 to 220 of about 402,887 (303)

p38 mitogen-activated protein kinase drives senescence in CD4⁺ T lymphocytes and increases their pathological potential. [PDF]

Immun Ageing
González-Osuna L, Fukada SY, Hernández-Cáceres MP, Luz-Crawford P, Cortez C, Rojas C, Carvajal P, Sierra-Cristancho A, Vernal R.   +8 more
europepmc   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Promotes Ovarian Cancer Tumorsphere Proliferation and Metastasis

International Journal of Cancer, EarlyView.
In high‐grade serous ovarian cancer, malignant ascites frequently arise as ovarian cancer cells shed from the primary tumor and aggregate into tumorspheres, severely limiting treatment success. To date, little is known about the mechanisms governing tumorsphere endurance and metastasis within the ascites once formed.
Núria Gendrau‐Sanclemente, Agnès Figueras, Ferran Medina‐Jover, Juan A. Marín‐Jiménez, Michelle De Leeuw, Tianyu Dai, Marina Moreno‐Mosquera, Andrea Morales, Marc Guiu, Josefina Casas, José Carlos Perales, Roger R. Gomis, Francesc Viñals   +12 more
wiley   +1 more source

Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors. [PDF]

J Med Chem
Ferjančič Benetik S, Proj M, Knez D, Košak U, Meden A, Krajšek K, Pišlar A, Horvat S, Švajger U, Tešić N, Pulkrabkova L, Soukup O, Skarka A, Andrys R, Brazzolotto X, Igert A, Nachon F, Dias J, Detka J, Gdula-Argasińska J, Wyska E, Szafarz M, Manik A, Płachtij N, Musílek K, Sałat K, Obreza A, Gobec S.   +27 more
europepmc   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Tomato mitogen-activated protein kinase: mechanisms of adaptation in response to biotic and abiotic stresses. [PDF]

Front Plant Sci
Shi Y, Zhang Z, Yan Z, Chu H, Luo C.
europepmc   +1 more source

Substrate Characterization of Mycobacterial Kinase PknG Revealing PknG‐KARS‐MAPK Phosphorylation Signaling Axis in Host

iMetaMed, EarlyView.
This study employed multi‐omics approaches to investigate the regulatory mechanism of Mycobacterium PknG on host cell processes. We found that host lysine‐tRNA ligase (KARS) is a potential substrate of PknG; and PknG can regulate the immune response by catalyzing the phosphorylation of KARS at T592 and T595 sites, affecting the phosphorylation level in
Nana Tian, Shuyu Xie, Yanqing Tang, Junjie Liang, Wenhan Zhu, Tianqi Liu, Yewen Sun, Yang Yang, Luoxi Zhang, Danfeng Wang, Chuyao Lin, Jinyu Jia, Minjia Tan, Jun‐Yu Xu   +13 more
wiley   +1 more source

The Apple Mitogen-Activated Protein Kinase <i>MdMAPK6</i> Increases Drought, Salt, and Disease Resistance in Plants. [PDF]

Int J Mol Sci
Li M, Gao H, Zhou M, Zhang Y, Jiang H, Li Y.   +5 more
europepmc   +1 more source

Mitogen-Activated Protein Kinase Kinase Inhibitor [PDF]

, 2020
openaire   +1 more source

Single‐cell transcriptomics reveals cellular heterogeneity and phenotypic transitions of smooth muscle cells in aortic dissection

iMeta, EarlyView.
We utilized single‐cell RNA sequencing (scRNA‐seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation.
Liang Shao, Fan Hu, Ling‐Na Zhao, Jian‐Ping Luo, Peng‐Tao Zou, Xiu Liu, Shao‐Yi Zheng, Cong Chen, Lin‐Xiong Ye, Yu‐Xuan Zhou, Jiaqi Zhang, Kaidi Jin, Ping Zhang   +12 more
wiley   +1 more source

Mitogen-activated protein kinase (MAPK) gene family identification reveals GhMPK10-mediated regulation of abiotic stress tolerance through protein kinase signaling cascades in cotton. [PDF]

BMC Plant Biol
Li Y, Su R, Wang K, Wang J, Zhang D.
europepmc   +1 more source