Results 31 to 40 of about 673,597 (383)

Genome-wide identification and transcriptional expression analysis of mitogen-activated protein kinase and mitogen-activated protein kinase kinase genes in Capsicum annuum

Frontiers in Plant Science, 2015
The tripartite mitogen-activated protein kinase (MAPK) signaling cascades have been implicated in plant growth, development, and environment adaptation, but a comprehensive understanding of MAPK signaling at genome-wide level is limited in Capsicum ...
Shuilin eHe, zhiqin eliu, zhiqin eliu, lanping eshi, lanping eshi, yanyan eliu, yanyan eliu, lei eshen, lei eshen, sheng eyang, sheng eyang, jinsen ecai, qian etang, qian etang, huanxin eyu, huanxin eyu, rongzhang ewang, rongzhang ewang, jiayu ewen, jiayu ewen, youquan elin, youquan elin, jiong ehu, jiong ehu, cailing eliu, cailing eliu, shaoliang emou   +26 more
doaj   +1 more source

Autophagic cell death associated to Sorafenib in renal cell carcinoma is mediated through Akt inhibition in an ERK1/2 independent fashion. [PDF]

PLoS ONE, 2018
OBJECTIVES:To fully clarify the role of Mitogen Activated Protein Kinase in the therapeutic response to Sorafenib in Renal Cell Carcinoma as well as the cell death mechanism associated to this kinase inhibitor, we have evaluated the implication of ...
Leticia Serrano-Oviedo, Marta Ortega-Muelas, Jesús García-Cano, María Ll Valero, Francisco J Cimas, Raquel Pascual-Serra, Diego M Fernandez-Aroca, Olga Roche, María J Ruiz-Hidalgo, Borja Belandia, José M Giménez-Bachs, Antonio S Salinas, Ricardo Sanchez-Prieto   +12 more
doaj   +1 more source

Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase [PDF]

, 2011
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity.
Abraham, Alizadeh, Angus, Asaduzzaman, Bellahcene, Benjamini, Bernard, Boucek, Branger, Chang, Checchia, Chen, Chen, Cheryl A. Hemingway, Chopra, Crackower, Cuenda, Cvijanovich, David A. Relman, Dhingra, Dong, Fourrier, Gentleman, Haralambous, Hariklia Eleftherohorinou, Hilger, Hotchkiss, Hubble, Jayne L. Dennis, Joanne L. Franklin, Kaminska, Kanehisa, Kishimoto, Kumar, Leblais, Levin, Liu, Liu, Ma, Martin, Mi, Michael Griffiths, Michael Levin, Mockridge, Narazaki, Nazima Pathan, Opal, Osuchowski, Padkin, Parasrampuria, Pathan, Pathan, Popper, Riedemann, Schumann, Shanley, Sian E. Harding, Simon J. Waddell, Smyth, Song, Su, Talmor, Victoria J. Wright, Waage, Wang, Watson, Yang, Yu, Zarubin   +68 more
core   +1 more source

Targeting MAPK in Cancer 2.0 [PDF]

, 2022
Mitogen-activated protein kinase (MAPK) pathways are prominently involved in the onset and progression of cancer [...
Rovida, Elisabetta, Tusa, Ignazia
core   +1 more source

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine (*)

Journal of Biological Chemistry, 1995
Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism.
J. Raingeaud, Shashi Gupta, J. S. Rogers, M. Dickens, Jiahuai Han, R. Ulevitch, R. Davis   +6 more
semanticscholar   +1 more source

ARABIDOPSIS ATMKK1 KNOCKOUT MUTANT FLOWERS UNDER SHORT DAY CONDITIONS [PDF]

Journal of Plant Development
There are a variety of conditions that regulate flowering time in Arabidopsis, but there are no reported instances mitogen-activated protein kinase pathways playing a decisive role in flowering time.
Chad CONROY, Khadijah M. NIZAM, Tim XING
doaj   +1 more source

Resolving the binding-kinase discrepancy in bacterial chemotaxis: A nonequilibrium allosteric model and the role of energy dissipation [PDF]

Proc. Natl. Acad. Sci. U.S.A. 120, e2303115120 (2023), 2023
The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the extracellular ligand concentration and adapt across a wide concentration range by undergoing methylation and ...
arxiv   +1 more source

Mitogen-activated protein kinases in atherosclerosis

Postępy Higieny i Medycyny Doświadczalnej, 2014
Intracellular signalling cascades, in which MAPK (mitogen-activated protein kinases) intermediate, are responsible for a biological response of a cell to an external stimulus. MAP kinases, which include ERK1/2 (extracellular signalling-regulated kinase), JNK (c-Jun N-terminal kinase) and p 38 MAPK, regulate the activity of many proteins, enzymes and ...
Wioletta Olejarz, Danuta Zapolska-Downar, Dorota Bryk   +2 more
openaire   +3 more sources

Thrombomodulin Regulation of Mitogen-Activated Protein Kinases [PDF]

International Journal of Molecular Sciences, 2019
The multifaceted role of mitogen-activated protein kinases (MAPKs) in modulating signal transduction pathways in inflammatory conditions such as infection, cardiovascular disease, and cancer has been well established. Recently, coagulation factors have also emerged as key players in regulating intracellular signaling pathways during inflammation. Among
Sumith R. Panicker, Hemant Giri, Alireza R. Rezaie, Alireza R. Rezaie, Xiaofeng Cai, Indranil Biswas   +5 more
openaire   +2 more sources

Mitogen-activated protein kinase cascades in Vitis vinifera

Frontiers in Plant Science, 2015
Protein phosphorylation is one of the most important mechanisms to control cellular functions in response to external and endogenous signals. Mitogen-activated protein kinases (MAPK) are universal signaling molecules in eukaryotes that mediate the ...
Birsen eÇAKIR, Ozan eKılıçkaya
doaj   +1 more source