Results 31 to 40 of about 520,457 (360)
Frontiers in Physiology, 2021 Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li +8 more
doaj +1 more source
Regulation of Cell Motility by Mitogen-activated Protein Kinase
Journal of Cell Biology, 1997 Cell interaction with adhesive proteins or growth factors in the extracellular matrix initiates Ras/ mitogen-activated protein (MAP) kinase signaling.
R. Klemke +5 more
semanticscholar +1 more source
The Plant Cell, 2018 Multiple pattern-recognition receptors activate mitogen-activated protein kinase cascades and trigger disease resistance in plants via direct phosphorylation and positive feedback regulation.
Guozhi Bi +9 more
semanticscholar +1 more source
Journal of Biomedical Science, 2017 Background MEK1 mutation and activated MAPK signaling has been found in patients with RASopathies and abnormal cardiac development. Previous studies have suggested that regulation of fetal MAPK signaling is essential for normal cardiac development.
Che-Chung Yeh +3 more
doaj +1 more source
MAPK signaling regulates the efficacy of chemoimmunotherapy
Molecular & Cellular Oncology, 2022 Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination.
François Ghiringhelli
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Cells, 2020 : Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj +1 more source
Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background and Aims: The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. An imbalance in this highly regimented process within the intestinal crypts is associated with several intestinal pathologies ...
Chang Li +11 more
doaj +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. [PDF]
PLoS ONE, 2014 Prostate cancer (PCa) is the second leading cause of cancer death in the US. Death from PCa primarily results from metastasis. Mitogen-activated protein kinase kinase 4 (MAP2K4) is overexpressed in invasive PCa lesions in humans, and can be inhibited by ...
Janet M Pavese +6 more
doaj +1 more source