Results 221 to 230 of about 423,744 (290)

Underlying Mechanism of Jiuwei Shengmai Powder in Improving Myocardial Hypoxia at High Altitude Based on Network Pharmacology and Molecular Docking

iLABMED, EarlyView.
The expression pathway of COX and the downstream mechanism of PGE. M: muscarinic receptor; PL: phospholipid; PLA2: phospholipase A2; AA: arachidonic acid; EP1: prostaglandin E1 receptor; EP2: prostaglandin E2 receptor; EP3: prostaglandin E3 receptor; EP4: prostaglandin E4 receptor.
Cong Wu, Yanjuan Zhu, Changpeng Xie, Haobo Liu, Yuanming Pan, Chang'e Liu   +5 more
wiley   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium

, 1999
Teresa Improta-Brears, A. Richard Whorton, Franca Codazzi, John D. York, Tobias Meyer, Donald P. McDonnell   +5 more
openalex   +1 more source

Single‐cell sequencing reveals the role of IL‐33+ endothelial subsets in promoting early gastric cancer progression

iMeta, EarlyView.
A single‐cell atlas was established to reveal the molecular characteristics of early gastric cancer (EGC). In combination with organoids, animal models, and clinical samples, it was found that subpopulations such as pit mucous‐like cell (PMC‐like), proliferating cell (PC), CH25H+ CD4+ T cell, IL‐33+ endothelial cell, and ADAMTSL2+ endothelial cell are ...
Li Zhou, Mei Yang, Chao Deng, Manqiu Hu, Suhua Wu, Kewen Lai, Lili Zhang, Zhiji Chen, Qin Tang, Qingliang Wang, Lu Chen, Runmin Zha, Yuanyuan Chen, Yibo Tan, Song He, Zhihang Zhou   +15 more
wiley   +1 more source

Effect of heat stress on mitogen-activated protein kinases in the hypothalamic-pituitary-gonadal axis of developing Wenchang chicks. [PDF]

Poult Sci, 2020
Li QH, Yu ZQ, Chen Z.
europepmc   +1 more source

Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-γ uses a different signaling pathway

, 1999
Pavel Kovarik, Dagmar Stoiber, Patrick A. Eyers, Rossella Menghini, Armin Neininger, Matthias Gaestel, Philip Cohen, Thomas Decker   +7 more
openalex   +1 more source

Investigation on Klebsiella pneumoniae in the field of extracellular vesicles

Interdisciplinary Medicine, EarlyView.
The role of extracellular vesicles in the pathogenicity and antibiotic resistance, as well as treatment and prevention of Klebsiella pneumoniae. Abstract Klebsiella pneumoniae (KP), recognized for its pronounced antibiotic resistance, is a prevalent agent of nosocomial infections such as hospital‐acquired pneumonia.
Junwei Wu, Yuheng Liu, Jin Su, Yi Yang, Haiyi Deng, Yilin Yang, Mengxi Yanglan, Xinyi Wu, Shiqi Luo, Yao Liao, Lifu Wang   +10 more
wiley   +1 more source

Functional Characterization of the MKC1 Gene of Candida albicans, Which Encodes a Mitogen-Activated Protein Kinase Homolog Related to Cell Integrity

, 1995
Federico Navarro, Miguel Sánchez, Jesús Plá, César Nombela   +3 more
openalex   +1 more source

Applications of bioactive herbal extracts in dressing materials for skin wound repair: Ingredients, mechanisms and innovations

Interdisciplinary Medicine, EarlyView.
Abstract The skin, as the body's largest organ, plays essential roles in protection, immune regulation, and homeostasis. Skin trauma, especially chronic wounds such as diabetic ulcers, poses significant clinical challenges. Traditional treatments, while often effective, can be costly and pose risks.
Boxiang Yang, Jingyuan Xu, Siyi Liu, Chaoying Wu, Yi Li, Mingqi Lv, Tingting Chen, Chuanrong Zhao, Daojun Pu, Chaojun Tang, Anna Malashicheva, Guangchao Zang, Guixue Wang   +12 more
wiley   +1 more source

The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase Activation

, 1999
Simon J. Cook, Natasha Aziz, Martin McMahon   +2 more
openalex   +1 more source