Results 211 to 220 of about 138,391 (258)
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The mitogen-activated protein kinase activator
Current Opinion in Cell Biology, 1992The mitogen-activated protein kinase appears to be regulated by another growth factor regulated kinase, the mitogen-activated protein kinase activator. In the past year, much progress has been made in purifying and characterizing the mitogen-activated protein kinase activator, in determining its primary structure, and in identifying another protein ...
N G, Ahn, R, Seger, E G, Krebs
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Mitogen-activated protein kinases in schizophrenia
Biological Psychiatry, 1999Mitogen-activated protein kinases (MAPKs) are important mediators of signal transduction from the cell surface to the nucleus and have been implicated in the integration of a variety of physiologic processes in most cells, including neurons. To investigate the possible involvement of MAPKs in schizophrenia, we compared the levels of the MAPK ...
S V, Kyosseva +5 more
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Mitogen-activated protein kinase pathways
Current Opinion in Cell Biology, 1997Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase cascades in their repertoire of signal transduction mechanisms. Recent advances in the study of such cascades include the cloning of genes encoding novel members of the cascades, further definition of the roles of the cascades in responses to extracellular ...
M J, Robinson, M H, Cobb
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Networking with mitogen-activated protein kinases
Molecular and Cellular Biochemistry, 1993Mitogen activated protein (MAP) kinases and their target ribosomal protein S6 (RSK) kinases have been recognized as shared components in the intracellular signaling pathways of many diverse cytokines. Recent studies have extended this protein kinase cascade by identifying the major activator of vertebrate MAP kinases as a serine/threonine/tyrosine ...
S L, Pelech +8 more
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European Journal of Pharmacology, 1999
Mitogen-activated protein kinases (MAPKs) are activated by various stimuli, such as growth factors, cytokines, or stress, and are considered to be important mediators in intracellular signal transduction networks. The dual-specificity kinases, MAPK kinases (MKKs), which phosphorylate the TXY motif in the catalytic domain of MAPKs, can cause the ...
M, Haneda, T, Sugimoto, R, Kikkawa
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Mitogen-activated protein kinases (MAPKs) are activated by various stimuli, such as growth factors, cytokines, or stress, and are considered to be important mediators in intracellular signal transduction networks. The dual-specificity kinases, MAPK kinases (MKKs), which phosphorylate the TXY motif in the catalytic domain of MAPKs, can cause the ...
M, Haneda, T, Sugimoto, R, Kikkawa
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Mitogen-Activated Protein Kinase Signaling
2004The mechanism by which cells respond to extracellular stimuli involves a series of signal transduction events across the cell membrane and through the cytoplasm to the nucleus. Mitogen-activated protein (MAP) kinases are important mediators of signal transduction and play a key role in the regulation of many cellular processes, such as cell growth and ...
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Mitogen-Activated Protein Kinase Assays
2007Polymorphonuclear neutrophils (PMN) play an essential role in host defense against bacteria and fungi through coordinated responses such as adhesion, migration, phagocytosis, secretion, and activation of the NADPH oxidase. The mitogen-activated protein kinases (MAPKs) and their activation kinase cascades, which transduce signals from the plasma ...
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Novel mitogen-activated protein kinase kinase inhibitors
Expert Opinion on Investigational Drugs, 2011the development of new drugs over the last few decades has targeted specific proteins thought to be a key to the disease state. MAPK kinases 1 and 2 (commonly known as MEK1-2) represent such proteins as they lie downstream of important drug targets for oncology, such as EGFR, RAS and RAF.
Mark S, Chapman, Jeffrey N, Miner
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Neuroscience, 1995
The sequential activation of the mitogen-activated protein kinase kinase and its substrate, the mitogen-activated protein kinase is involved in a cascade of protein kinases which link a number of cell surface signals to intracellular changes in enzyme activity and gene expression.
T, Arendt +4 more
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The sequential activation of the mitogen-activated protein kinase kinase and its substrate, the mitogen-activated protein kinase is involved in a cascade of protein kinases which link a number of cell surface signals to intracellular changes in enzyme activity and gene expression.
T, Arendt +4 more
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Activation of Mitogen‐Activated Protein Kinases in Oligodendrocytes
Journal of Neurochemistry, 1996Abstract: The proliferation and differentiation of oligodendrocyte progenitors are stringently controlled by an interacting network of growth and differentiation factors. Not much is known, however, about the intracellular signaling pathways activated in oligodendrocytes. In this study, we have examined the activation of mitogen‐activated protein (MAP)
N R, Bhat, P, Zhang
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