Results 41 to 50 of about 90,988 (285)

Prevention of Intraabdominal Adhesions: An Experimental Study Using Mitomycin-C and 4% Icodextrin

Balkan Medical Journal, 2017
Background: Intraabdominal adhesions remain a significant cause of morbidity and mortality. Moreover, intraabdominal adhesions can develop in more than 50% of abdominal operations.
Murat Urkan, İsmail Hakkı Özerhan, Aytekin Ünlü, Mehmet Fatih Can, Erkan Öztürk, Armağan Günal, Gökhan Yağcı   +6 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Resolution of primary acquired melanosis with atypia after treatment with topical mitomycin C and interferon alfa-2b

Journal of Ophthalmic & Vision Research, 2015
Purpose: To report a case of primary acquired melanosis (PAM) successfully treated with combined topical mitomycin C and interferon-α2b. Case Report: A 75-year-old man presented with an extensive unilateral pigmented lesion involving 360° of the bulbar
Fariba Ghassemi, Hadi Ghadimi, Mojgan Nikdel   +2 more
doaj   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Repurposing Mitomycin C in Combination with Pentamidine or Gentamicin to Treat Infections with Multi-Drug-Resistant (MDR) Pseudomonas aeruginosa

Antibiotics
The aims of this study were (i) to determine if the combination of mitomycin C with pentamidine or existing antibiotics resulted in enhanced efficacy versus infections with MDR P.
Elin Svedholm, Benjamin Bruce, Benjamin J. Parcell, Peter J. Coote   +3 more
doaj   +1 more source

Tocotrienol inhibits proliferation of human Tenon's fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin C [PDF]

, 2018
Purpose: To evaluate the potential of the vitamin E compound α-tocotrienol as antifibrotic agent in vitro. Methods: Using human Tenon's capsule fibroblast cultures, the antiproliferative and cytotoxic effects of the different vitamin E forms α-tocopherol,
Azzi, Angelo, Frueh, Beatrice, Goldblum, David, Kilchenmann, Monika, Meyenberg, Alexander, Nesaretnam, Kalanithi, Zingg, Jean-Marc   +6 more
core  

Antitumor effect of therapeutic HPV DNA vaccines with chitosan-based nanodelivery systems [PDF]

, 2014
Cervical cancer is the second-most-common cause of malignancies in women worldwide, and the oncogenic activity of the human papilloma virus types (HPV) E7 protein has a crucial role in anogenital tumors.
Atyabi, F., Ghaemi, A., Gorji, A., Kalhor, H.R., Kelishadi, M., Moradi, A., Sajadian, A., Tabarraei, A., Tahamtan, A.   +8 more
core   +3 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

Frequency analysis of cytolytic T cell precursors (CTL-P) generated in vivo during lethal rabies infection of mice. I. Distinction of CTL-P with different interleukin 2 sensitivity [PDF]

, 1982
The aim of this study was to determine the number and state of activity of cytolytic T lymphocytes (CTL) and their precursors (CTL-P) present in vivo during the early stages of viral infection. The local response to lethal infection with rabies virus was
Cerottini, Fischer Lindahl, Gillis, Hardt, Komatsu, Koszinowski, Lagrange, Lefkovits, Miller, Plate, Ryser, Schneider, Skinner, Smith, Smith, Teh, Wagner, Wagner, Wiktor, Wiktor, Wiktor, Zinkernagel   +21 more
core   +1 more source

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Advanced Science, EarlyView.
Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li, Zexuan Zhang, Zihan Xie, Cheng Jin, Zhipeng Wang, Changwei Yuan, Jun Zhu, Jielin Tang, Mengzhen Li, Dingfeng Zou, Xinyu Mang, Jun Liu, Dingyao Chen, Qi Geng, Yan Lu, Ning Zhang, Shiying Miao, Jing Peng, Kai Li, Wei Song   +19 more
wiley   +1 more source