Results 101 to 110 of about 59,323 (260)

Mitomycin Betaines:  Synthesis, Structure, and Solvolytic Reactivity^†

, 2016
7-N-[2-(Methylamino)ethyl]mitomycin C (2b) and 7-N-[2-(ethylamino)ethyl]mitomycin C (2c) underwent rapid C(8) cyclization and oxidation to generate the novel quinoxaline mitomycin betaines 5a,b, respectively.
Harold Kohn (1333722), Shuang Wang (46453)   +1 more
core   +1 more source

Ischaemic stroke and 5‐fluorouracil or capecitabine: A systematic review and meta‐analysis of harms and a retrospective study of the WHO pharmacovigilance database

British Journal of Pharmacology, EarlyView.
Abstract Aim Fluoropyrimidines, including 5‐fluorouracil (5‐FU) and capecitabine, are cornerstone antineoplastic agents for cancer. Case reports suggest that these drugs may be associated with an under‐recognised risk of ischaemic stroke or transient ischaemic attack (TIA).
Sophie Nguyen, Ines Bentahrour, Camille Guerin, Charles Dolladille, Angélique Da Silva, François Cherifi, Elise‐Marie Minoc, Pierre‐Marie Morice, Nicolas Jacquin, Christophe Le Tourneau, Joachim Alexandre, Ahmad Nehme, Etienne Bastien   +12 more
wiley   +1 more source

Resolution of primary acquired melanosis with atypia after treatment with topical mitomycin C and interferon alfa-2b

Journal of Ophthalmic & Vision Research, 2015
Purpose: To report a case of primary acquired melanosis (PAM) successfully treated with combined topical mitomycin C and interferon-α2b. Case Report: A 75-year-old man presented with an extensive unilateral pigmented lesion involving 360° of the bulbar
Fariba Ghassemi, Hadi Ghadimi, Mojgan Nikdel   +2 more
doaj   +1 more source

Diamond burr superficial keratectomy with mitomycin C for corneal scarring and high corneal astigmatism after pterygium excision

, 2013
Engin Bilge Ozgurhan,1 Necip Kara,1 Aydin Yildirim,2 Zeynep Alkin,1 Ercument Bozkurt,1 Ahmet Demirok1,31Beyoglu Eye Research and Training Hospital, 2Department of Ophthalmology, Sema Research and Treatment Hospital, Fatih University, 3Department of ...
Demirok A, Bozkurt E, Kara N, Yildirim A, Alkin Z, Ozgurhan EB   +5 more
core  

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Subconjunctival bevacizumab to augment trabeculectomy with mitomycin C in the management of failed glaucoma surgery

, 2014
Ahmed M Saeed, Tarek Tawfeek AboulNasrOphthalmology Department, Benha University, Egypt Purpose: To provide a feasible solution to the problem of failed glaucoma surgery.
Saeed AM, AboulNasr TT
core  

Trabeculectomy with Mitomycin C

Fornix based trabeculectomy with mitomycin ...
Teng, Christopher, eyeMoviePedia gGmbH, Liebmann, Jeffrey M.   +2 more
core   +1 more source

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source

cellcycle effects of mitomycin C

, 2003
ZELLZYKLUSEFFEKTE VON MITOMYCIN C Im Rahmen dieser Arbeit sollten die durch Mitomycin C (MMC) exogen induzierten Zellzyklusstörungen mit den endogenen Störungen des Zellzyklus bei Fanconi-Anämie in unterschiedlichen Zellsystemen (periphere ...
Endres, Karlheinz
core  

Physiological media and oxygen levels modulate cancer hallmarks in cultured breast cancer cells

The FEBS Journal, EarlyView.
MCF7 breast cancer cells were cultured in standard conditions (18% O2 and DMEM) and physiological conditions (5% O2 and Plasmax, a medium modeled after the human plasma metabolome). A combined transcriptomic and proteomic approach was used to identify gene expression signatures at the mRNA and protein levels upstream of functional enrichment analyses ...
Jacob E. Wiebe, Ricardo Alva, Fereshteh Moradi, Sarah Alderman, Ping Liang, Jeffrey A. Stuart   +5 more
wiley   +1 more source