Results 121 to 130 of about 59,323 (260)

Safety and Efficacy of Topical Mitomycin C in Myringotomy Patency

, 2001
OBJECTIVE: To develop an alternative method for prolonged middle ear ventilation using topical mitomycin C. STUDY DESIGN AND SETTING: Twenty guinea pigs with normal ears had bilateral myringotomies performed using the argon laser.
Orlando Gomez‐Marin, Jassir, David, Buchman, Craig A, Craig A. Buchman, Gomez-Marin, Orlando, David Jassir   +5 more
core   +1 more source

Ectonucleotidases CD39 and CD73 expression levels are independent and inverse predictors of survival in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Bladder cancer is one of the leading causes of cancer‐related mortality worldwide. Long‐term survival is particularly poor in patients with muscle‐invasive bladder cancer (MIBC). Modulation of purinergic signaling through the ectonucleotidases CD39 and CD73 has emerged as a promising therapeutic strategy in cancer medicine.
Stephan Ledderose, Julia Schwenke, Lennert Eismann, Severin Rodler, Martina Rudelius, Carola Ledderose   +5 more
wiley   +1 more source

R17 Drives Heparan Sulfate Clearance via Endolysosomal Trafficking

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
R17 is a viral protein that binds heparan sulfate glycosaminoglycans and traffics them to the lysosome, leading to their degradation in a manner that does not require the presence of the cation‐independent mannose‐6‐phosphatre receptor. In BxPC3 pancreatic cancer cells, this loss in heparan sulfate results in the reduction of cell migration.
Pranali Bedekar, Alexander Lin, Abigail E. Reeves, Meg Critcher, Gil‐Suk Yang, Sean Hui, Daved H. Fremont, Mia L. Huang   +7 more
wiley   +1 more source

Nucleophilic Activation of a Tetra-Substituted Mitomycin Cyclic Bis-Disulfide

, 2009
The multimerization of functional DNA alkylating agents has drawn significant, recent interest because these compounds are expected to generate enhanced levels of DNA cross-linked adducts, compared with their monomeric agents.
Lee, Sang Hyup, Kohn, Harold
core   +1 more source

Recycling of hazelnut waste: Antidiabetic properties of soy lecithin nanoparticles and their in vitro anti‐proliferative effects in tumor cell lines

Journal of the Science of Food and Agriculture, Volume 106, Issue 9, Page 5596-5613, July 2026.
Abstract BACKGROUND Hazelnuts and foods produced using hazelnuts are consumed with pleasure, but it is important to evaluate the waste generated during hazelnut processing and determine their usage methods. RESULTS This study was conducted to determine the changes in bioactive components, bioaccessibility and antidiabetic activity of nanoparticles ...
Mehmet Ali Temiz, Emine Okumus
wiley   +1 more source

Long‐term outcomes following a 5‐year recurrence‐free interval in non‐muscle‐invasive bladder cancer

BJU International, Volume 138, Issue 1, Page 125-132, July 2026.
Objective To describe the recurrence and progression trends of non‐muscle‐invasive bladder cancer (NMIBC) during a 14‐year period in Denmark between 2009 and 2022. Furthermore, to evaluate the risk of late recurrence with or without progression in patients who initially experience a 5‐year recurrence‐free interval (RFI).
Peter B. Hjort, Jørgen B. Jensen, Andreas Ernst   +2 more
wiley   +1 more source

Surgical excision of melanomas in the anal region and reconstruction of the anus in 11 horses

Equine Veterinary Education, Volume 38, Issue 7, Page e387-e398, July 2026.
Summary This case report describes the surgical excision of large perianal and perineal melanomas, and reconstruction of the anus in 11 grey horses. Four horses had a history of painful defaecation or urination due to extensive tumours. Seven horses had no clinical signs at the time of admission but had rapidly growing nodules around the anus with ...
F. Somm, A. E. Fürst, M. A. Jackson
wiley   +1 more source

Does titration of mitomycin C as an adjunct to trabeculectomy significantly influence the intraocular pressure outcome?

, 2008
Susan J Lee1, Augusto Paranhos2, M Bruce Shields11Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut, USA; 2Federal University of São Paulo, São Paulo, BrazilPurpose: To ...
Augusto Paranhos, Susan J Lee, M Bruce Shields   +2 more
core  

Combining cisplatin and mitomycin with radiotherapy in anal carcinoma.

, 2007
International audiencePURPOSE: The European Organization for Research and Treatment of Cancer (EORTC) phase II study No. 22953 demonstrated the feasibility of reducing the overall treatment time of chemoradiation, delivering mitomycin C twice rather than
Mercier, Mariette, Bosset, Mathieu, Buffet-Miny, Joëlle, Crehange, Gilles, Dumas, Jean Luc, Lorchel, Fabrice, Puyraveau, Marc, Bosset, Jean François   +7 more
core   +1 more source

Pegargiminase Suppresses the Fanconi Anemia Pathway and Promotes Melphalan‐Induced DNA Double‐Strand Breaks in Uveal Melanoma

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
ADI‐PEG20 enhances melphalan‐induced DNA DSBs in UM cells. We describe potentiation of DNA DSBs in UM cell lines upon treatment with ADI‐PEG20 and melphalan (92.1 cells with STRIDE by intoDNA). ADI‐PEG20 suppresses multiple members of the FA pathway—a known resistance mechanism for melphalan—providing a rationale for exploring this drug combination in ...
Iuliia Pavlyk, George Field, Matthew Young, Josephine Carpentier, Emilia A. Szlosarek, Michaela R. O'Keeffe‐Brown, Timothy Crook, Nelofer Syed, John S. Bomalaski, Pui Ying Chan, Peter W. Szlosarek   +10 more
wiley   +1 more source