Results 121 to 130 of about 98,698 (295)
Can Epirubicin Be Used in Laryngology Practice Like Mitomycin? An Experimental and Pioneering Study [PDF]
Iranian Journal of OtorhinolaryngologyIntroduction: Epirubicin and mitomycin-C share similar mechanisms of action, with both exhibiting antiproliferative effects by inhibiting DNA and protein synthesis.
Erdem Koroglu +5 more
doaj +1 more source
Phase II trial of irinotecan, cisplatin and mitomycin for relapsed small cell lung cancer [PDF]
, 2007 Dean A. Fennell +7 more
openalex +1 more source
Surgical excision of melanomas in the anal region and reconstruction of the anus in 11 horses
Equine Veterinary Education, EarlyView.Summary This case report describes the surgical excision of large perianal and perineal melanomas, and reconstruction of the anus in 11 grey horses. Four horses had a history of painful defaecation or urination due to extensive tumours. Seven horses had no clinical signs at the time of admission but had rapidly growing nodules around the anus with ...
F. Somm, A. E. Fürst, M. A. Jackson
wiley +1 more source
Limited roles of the miR‐17‐92 cluster in the regulation of T‐cell apoptosis
The FEBS Journal, EarlyView.The pro‐apoptotic protein BIM shapes T‐cell survival and function, but how it is regulated remains unclear. In a mouse model lacking direct miR‐17‐92:Bim interactions, we observed a moderate reduction in Th17 CD4+ T cells. BIM levels were modestly increased in double‐positive thymocytes and naive CD8+ T cells, but this did not affect overall T‐cell ...
Katharina Hoppe +7 more
wiley +1 more source
AntibioticsThe aims of this study were (i) to determine if the combination of mitomycin C with pentamidine or existing antibiotics resulted in enhanced efficacy versus infections with MDR P.
Elin Svedholm +3 more
doaj +1 more source
Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C [PDF]
, 2007 The modern era of targeted therapeutics offers the potential to tailor therapy to individual patients whose tumours express a specific target. Previous attempts to forecast tumour response to conventional chemotherapeutics based on similar principles ...
Phillips, Roger M, Volpato, Milene
core
GCN2 in proteostasis: structural logic, signalling networks and disease
The FEBS Journal, EarlyView.Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Upper tracheal stenosis (UTS) is a rare process with multiple causes and variable approaches to treatment. Australian data on management patterns are lacking and patient resources reflecting local practices are scarce. Aims To describe the management strategies of UTS over 12 years among three teaching hospitals in New South Wales ...
Nathan Harb +6 more
wiley +1 more source
Physicochemical stability of urea-containing Mitomycin C preparations in glass vials (1.0 mg/mL) and plastic syringes (2.0, 0.4, 0.2 mg/mL) [PDF]
, 2023 Jannik Almasi +3 more
openalex +1 more source
Journal of Gastroenterology and Hepatology, EarlyView.ABSTRACT Intrahepatic cholangiocarcinoma (iCCA) ranks as the second most common primary liver cancer, compared to about 20% of cases. Its global incidence has climbed over the past four decades, yet early detection remains indefinable due to its asymptomatic nature. Five‐year survival rate of approximately is under 10%.
Yaqoob Muhammad +10 more
wiley +1 more source