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Mitomycins syntheses: a recent update
Beilstein Journal of Organic Chemistry, 2009 Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. They have been used in clinics since the 1960’s, and the challenges represented by their total synthesis have challenged ...
Jean-Christophe Andrez
doaj +2 more sources
Cytotoxicity, crosslinking and biological activity of three mitomycins [PDF]
Bioorganic Chemistry, 2022 Shu-Yuan Cheng +2 more
exaly +2 more sources
In vitro characterization of MitE and MitB: Formation of N-acetylglucosaminyl-3-amino-5-hydroxybenzoyl-MmcB as a key intermediate in the biosynthesis of antitumor antibiotic mitomycins [PDF]
, 2019 Mitomycins, produced by several Streptomyces strains, are potent anticancer antibiotics that comprise an aziridine ring fused to a tricyclic mitosane core. Mitomycins have remarkable ability to crosslink DNA with high efficiency.
Yoshimitsu Hamano +9 more
core +1 more source
Angewandte Chemie, EarlyView.This study employs a RuV═NH complex with hydrogen‐bonding (HB) sites in the SCS to afford non‐N‐substituted aziridines selectively. Nitrogen‐atom transfer occurs from the RuV═NH complex to alkenes in water to produce aziridine derivatives in high yields.
Tomoya Ishizuka +7 more
wiley +2 more sources
Microbial Resistance to Mitomycins Involves a Redox Relay Mechanism
, 2016 Microbial Resistance to Mitomycins Involves a Redox Relay ...
Hung-wen Liu (1279131) +4 more
core +1 more source
Synthesis of indolequinones. New synthetic route to the pyrrolo[1,2- α ]indole ring systems [PDF]
, 1973 The thermal decomposition of 2-azido-3-vinyl-1,4-quinones results in their smooth ring closure to indole-4,7-diones (indolequinones related to the biologically significant mitomycins)
Germeraad, Paul, Moore, Harold W
core +1 more source
Studies towards enantioselective synthesis of mitomycins A and B series
, 2017 of thesis entitled STUDIES TOWARDS ENANTIOSELECTIVE SYNTHESIS OF MITOMYCINS A AND B SERIES Submitted by Sui Yi for the degree of Doctor of Philosophy at The University of Hong Kong in May 2017 Mitomycins are a large family of natural products with
Sui, Yi, 隋毅
core +1 more source
Synthesis, DNA Cross-Linking Activity, and Cytotoxicity of Dimeric Mitomycins
, 2016 Dimeric DNA cross-linking compounds have emerged as important new antitumor agents. We report the synthesis and biochemical evaluation of a select set of dimeric mitomycins in which the two mitomycin units are tethered at either the mitomycin C(7) amino ...
Harold Kohn (1333722) +4 more
core +1 more source
, 2022 Mitomycins are a family of naturally occurring, potent alkylating agents in which the C member has been clinically used for cancer chemotherapy for over 5 decades.
Qian Yang (300330) +4 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source