Results 281 to 290 of about 124,344 (344)

Combatting bacterial infections by killing persister cells with mitomycin C.

Environmental Microbiology, 2015
Persister cells are a multi-drug tolerant subpopulation of bacteria that contribute to chronic and recalcitrant clinical infections such as cystic fibrosis and tuberculosis.
Brian W. Kwan, N. Chowdhury, T. Wood
semanticscholar   +1 more source

Mitomycine, suterelysis and hypotony

International Ophthalmology, 1992
In 35 patients 37 trabeculectomies (TE) were performed using mitomycin as a fibrosisinhibitor. Mitomycin (0.5 mg/ml) was applied to the sclera (under the scleral flap) and conjunctiva in the area of the projected TE during 5 minutes using a small sponge.
H. Caroline Geijssen, Erik L. Greve
openaire   +2 more sources

Structure activity relationship for mitomycin C and mitomycin A analogs

Journal of Medicinal Chemistry, 1991
A set of 30 mitomycin C and mitomycin A analogues, including five new compounds, was screened against three different solid human tumor cell lines using the MTT tetrazolium dye assay. A statistically significant correlation among antitumor activity, quinone reduction potential (E1/2), and the logarithm of the partition coefficient (log P) was obtained,
Bhashyam S. Iyengar, David S. Alberts, Kenneth R. Kunz, Robert T. Dorr, William A. Remers   +4 more
openaire   +3 more sources

Enantioselective Synthesis of (+)-Mitomycin K by a Palladium-Catalyzed Oxidative Tandem Cyclization.

Angewandte Chemie, 2017
The mitomycins, a family of bioactive natural products, feature a compact 6/5/5-fused polycyclic ring structure densely decorated with highly reactive and/or fragile quinone, amino ketal, and aziridine as well as carbamate moieties.
Qiangshuai Gu, Dan Yang
semanticscholar   +1 more source

EpiLASIK with Mitomycin C

European Journal of Ophthalmology, 2010
Purpose Mitomycin C after photorefractive keratectomy (PRK) is used to reduce the development of haze and regression in higher intended corrections. The aim of this study was to investigate the safety, stability, and efficacy of EpiLASIK with mitomycin C. Methods Fifty eyes of 29 patients underwent EpiLASIK with the Gebauer EpiLift microkeratome.
Chris P. Lohmann, Ramin Khoramnia, Christoph Winkler von Mohrenfels, Mathias Maier   +3 more
openaire   +3 more sources

Pulmonary toxicity of mitomycin

Cancer, 1980
Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progressing to interstitial pulmonary ...
Mario A. Luna, Gabriel N. Hortobagyi, Charles K. Tashima, Aman U. Buzdar, Sewa S. Legha, George R. Blumenschein   +5 more
openaire   +3 more sources

Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study.

Journal of Clinical Oncology, 1996
PURPOSE Definitive chemoradiation (CR) has replaced radical surgery as the preferred treatment of epidermoid carcinoma of the anal canal. To determine the importance of mitomycin (MMC) in the standard CR regimen and to assess the role of salvage CR in ...
M. Flam, M. John, Thomas F. Paajk, N. Petrelli, R. Myerson, Scott Doggett, J. Quivey, M. Rotman, Herbert Kerman, Lawrence Cola, K. Murray   +10 more
semanticscholar   +1 more source

Stability of mitomycin admixtures

American Journal of Health-System Pharmacy, 1985
The stability of mitomycin in admixtures for continuous intravenous infusion was studied. Mitomycin was reconstituted and diluted to 50 micrograms/mL in polyvinyl chloride minibags containing 5% dextrose injection 50 mL or 0.9% sodium chloride injection 50 mL.
Robert K. Ausman, Edward J. Quebbeman, Ahmed A. R. Hamid, Norman E. Hoffman   +3 more
openaire   +3 more sources

Fluorouracil, mitomycin, and radiotherapy vs fluorouracil, cisplatin, and radiotherapy for carcinoma of the anal canal: a randomized controlled trial.

Journal of the American Medical Association (JAMA), 2008
CONTEXT Chemoradiation as definitive therapy is the preferred primary therapy for patients with anal canal carcinoma; however, the 5-year disease-free survival rate from concurrent fluorouracil/mitomycin and radiation is only approximately 65 ...
J. Ajani, K. Winter, L. Gunderson, J. Pedersen, A. Benson, Charles R. Thomas, R. Mayer, M. Haddock, T. Rich, C. Willett   +9 more
semanticscholar   +1 more source

The Mitomycins and Porfiromycins

1967
The mitomycins and porfiromycins form a group of closely related bactericidal and cytotoxic antibiotics produced by several Streptomyces species. They all can be derived from a common structure, the trivial name of which is mitosane (I, Fig. 1), as first recognized and named by WEBB et al. (1962).
V. N. Iyer, Waclaw Szybalski
openaire   +2 more sources