Results 291 to 300 of about 124,344 (344)
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Cancer Treatment Reviews, 1976
Summary Preclinical 1. Mitomycin C is an alkylating agent requiring reduction of the quinone to be active. 2. The aziridine ring is essential for the antitumor activity of mitomycin C. 3. The degree of DNA cross-linking and tumor inhibition is proportional to the guanine and cytosine content of the DNA. 4.
William T. Bradner, Stanley T. Crooke
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Summary Preclinical 1. Mitomycin C is an alkylating agent requiring reduction of the quinone to be active. 2. The aziridine ring is essential for the antitumor activity of mitomycin C. 3. The degree of DNA cross-linking and tumor inhibition is proportional to the guanine and cytosine content of the DNA. 4.
William T. Bradner, Stanley T. Crooke
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1979
The mitomycins were first obtained in 1956 from Streptomyces caespitosus by Hata and coworkers in Japan (1, 2). The isolation involved alumina chromatography of the chloroform extracts of the concentrated aqueous filtrates of the fermentation broth. Although there were many active components in the eluted fractions, only two antibiotics, mitomycins A ...
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The mitomycins were first obtained in 1956 from Streptomyces caespitosus by Hata and coworkers in Japan (1, 2). The isolation involved alumina chromatography of the chloroform extracts of the concentrated aqueous filtrates of the fermentation broth. Although there were many active components in the eluted fractions, only two antibiotics, mitomycins A ...
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Journal of Medicinal Chemistry, 1986
AbstractMetallkomplexe wie (I) und (II) aus Mitomycin‐Derivaten sowie (III) werden dargestellt, und ihre Aktivität gegen P388‐Leukä‐ mie wird untersucht.
Bhashyam S. Iyengar +3 more
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AbstractMetallkomplexe wie (I) und (II) aus Mitomycin‐Derivaten sowie (III) werden dargestellt, und ihre Aktivität gegen P388‐Leukä‐ mie wird untersucht.
Bhashyam S. Iyengar +3 more
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Cardiotoxicity of mitomycin A, mitomycin C, and sevenN 7 analogs in vitro
Cancer Chemotherapy and Pharmacology, 1992The alkylating antitumor agents mitomycin A (MMA), mitomycin C (MMC), and seven N7 analogs were compared in terms of their cardiotoxic and antitumor activity in vitro. Neonatal rat-heart myocytes were sensitive to five of the compounds studied, including MMA, 7-dimethylamidinomitosane (BMY-25282), 7-(N-methyl-piperazinyl)-mitosane (RR-194), N7-(4 ...
Nancy G. Shipp +5 more
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Phytosomes loaded with mitomycin C-soybean phosphatidylcholine complex developed for drug delivery.
Molecular Pharmaceutics, 2013A novel formulation system of phytosomes loaded with mitomycin C-soybean phosphatidylcholine (MMC-SPC) complex (MMC-loaded phytosomes) was prepared by a solvent evaporation method combined with a nanoprecipitation technique for the purpose of development
Zhenqing Hou +10 more
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1990
This chapter describes mitomycin syntheses published in the period 1984–1988 plus 1989 literature available by August 1. Mitomycin synthesis was intensively investigated in this period. It is characterized by a considerable variety of strategies and novel chemistry. The most significant accomplishment was an efficient new total synthesis of mitomycin С
Bhashyam S. Iyengar, William A. Remers
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This chapter describes mitomycin syntheses published in the period 1984–1988 plus 1989 literature available by August 1. Mitomycin synthesis was intensively investigated in this period. It is characterized by a considerable variety of strategies and novel chemistry. The most significant accomplishment was an efficient new total synthesis of mitomycin С
Bhashyam S. Iyengar, William A. Remers
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Structural studies of mitomycins. V. Structure of mitomycin H [PDF]
Acta Crystallographica Section C Crystal Structure Communications, 1991 C 15 H 16 N 2 O 4 cristallise dans P2 1 2 1 2 1 avec a=10,929, b=13,446, c=9,686 A, Z=4; affinement jusqu'a R=0,039. Dans ce compose, le groupe carbamate, l'un des groupes fonctionnels caracteristiques de la mitomycine, est remplace par une liaison exocyclique −C=C−.
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Bacteriocidal action of mitomycin C
Biochimica et Biophysica Acta, 1960Abstract The bacteriocidal action of Mitomycin C has been investigated with respect to its biochemical, genetic and morphological correlates. All findings are consistent with the observation that cells treated with Mitomycin lose DNA, but not RNA or protein, to the surrounding medium.
Edward L. Tatum, A.J. Shatkin, E. Reich
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Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential
Biochemistry, 1991The mitomycins are a group of antitumor antibiotics that covalently bind to DNA upon reductive activation. Mitomycin A (1b; MA) is more toxic than its clinically useful mitomycin C (1a; MC). The greater toxicity of mitomycin A has been previously attributed to its higher reduction potential.
Roselyn Lipman +4 more
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Structural Studies of Mitomycins. VIII. Mitomycin D Hydrate, C15H18N4O5.1.5H2O
Acta Crystallographica Section C Crystal Structure Communications, 1996The title compound, [1aS]-6-amino-1, 1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino++ +[2',-3': 3,4]pyrrolo[1,2-a]indol-7-ylmethyl, is a mitomycin derivative, mitomycins being antitumor antibiotics. The O atoms of the quinone ring deviate significantly from the least-squares plane through the quinone ring.
M. Kasai, Noriaki Hirayama, Hitoshi Arai
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