Results 301 to 310 of about 124,344 (344)

The chemistry of mitomycins

1990
The mitomycins are a group of antibiotics, discovered in Japan in the 1950s in fermentation cultures of certain strains of Streptomyces 1. Observation of their significant antitumour activity soon followed and today, one of the drugs, mitomycin C, is widely used in clinical anticancer chemotherapy2.
R. W. Franck, Maria Tomasz
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Impact of Mitomycin-C Application Time on the Scleral Mitomycin-C Concentration

Journal of Ocular Pharmacology and Therapeutics, 2001
The aim of this study was to determine the effect of varying the application time of Mitomycin-C (MMC) on the scleral concentration of MMC. The sclerae of 14 human donor eyes were used for this study. The episcleral sides of the 4 scleral quadrants of each donor eye were exposed for 0.5, 1, 3 and 5 min to round, 8 mm-diameter sponges soaked with 50 ...
S. Radda, I El Menyawi, Clemens Vass, Michael Georgopoulos, P. Nimmerrichter   +4 more
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Comparative reactivities of mitomycin C, 7-(N-piperidino)mitomycin, and mitomycin A. The role of the C(7) substituent

Journal of the American Chemical Society, 1993
Mitomycin C (1a) is considered to be the protypical bioreductive alkylating agent. Enzymatic reduction leads to activation of the two DNA-bonding sites (C(1) and C(10)) in 1a, permitting the formation of intrahelical interstrand DNA-mitomycin C cross-link adducts.
Suganthini Subramaniam, Harold Kohn
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Mitomycin C (z.B. Mitomycin C „Kyowa“)

2006
aufgrund zahlreicher Berichte uber Nekrosen wird Mitomycin C als gewebsnekrotisierend ...
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Reductive Activation of Mitomycin A by Thiols

Organic Letters, 2001
[reaction: see text]. Mitomycin C is unchanged upon exposure to thiols under physiological conditions. Its more toxic variant, mitomycin A (MA), undergoes elimination of methanol to give a variety of mitosene derivatives, diagnostic of its activation to a reactive electrophile. Evidence is presented for a novel reductive mechanism, characterized by the
Manuel M. Paz, Maria Tomasz
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Approaches to the mitomycins. Photochemistry of aminoquinones

The Journal of Organic Chemistry, 1977
Xylochinon (I) liefert unter hoher Verdunnung mit Pyrrolidin (II) das Addukt (III), dessen Photolyse zum Cyclisierungsprodukt (IV) fuhrt.
Smith Sp, Falci Kj, Franck Rw
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Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

Chemical Reviews, 2005
1. Introduction 7392. Bleomycin 7392.1. Discovery and Biological Activities 7392.2. Clinical Resistance 7402.2.1. Bleomycin Hydrolase 7412.2.2. Enhanced DNA Repair 7422.2.3. Bleomycin Binding Protein 7422.2.4. Other Mechanisms 7432.3.
Ute Galm, M. Hager, S. V. Van Lanen, J. Ju, J. Thorson, B. Shen   +5 more
semanticscholar   +1 more source

Mitomycins and the bleaching of Euglena gracilis

Archiv für Mikrobiologie, 1969
The effects of some mitomycin antibiotics on the chloroplast system of Euglena gracilis were studied. Only those derivatives which contained an alkyl group on the aziridine nitrogen were effective bleaching agents. Thus, only N-methyl-mitomycin, porfiromycin, and mitomycin B caused a highly significant loss of chloroplasts.
J. L. Mego, L. Ebringer, A. Jurášek
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A Synthetic Approach to the Mitomycins

HETEROCYCLES, 1978
AbstractDie Chinone (I) reagieren unter Bestrahlung zu den Hydrochinonen (II), welche zu den Chinonen (III) oxidiert werden können.
M. Akiba, Y. Kosugi, Toyozo Takada
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Mitomycin C extravasation injuries

Cancer, 1983
Mitomycin C extravasation produces a chronic painful ulceration similar to that of adriamycin. Pain marks the extravasation of this chemotherapeutic agent when it occurs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up.
Ernest K. Manders, Louis C. Argenta
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