Single-peptide DNA-dependent RNA polymerase homologous to multi-subunit RNA polymerase [PDF]
, 2017 Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a B400 kDa five-subunit catalytic core.
Forrest, David +3 more
core +2 more sources
Differentiation of Fanconi Anaemia (FA) from Idiopathic Aplastic Anaemia by Mitomycin - C (MMC) Stress Test [PDF]
Walawalkar International Medical Journal, 2020 Introduction and Background: Fanconi Anaemia (FA), an autosomal recessive disorder is one of the most common amongst hereditary causes of idiopathic aplastic anaemia with a worldwide incidence of 1 in 1, 60,000 individuals.
Sowmya Gayatri C1,2, Ashwin B. Dalal1 and Usha R. Dutta1
doaj
EFFICACY OF SEQUENTIAL BCG AND MITOMYCIN VERSUS MITOMYCIN ALONE FOR TREATMENT OF SUPERFICIAL BLADDER CANCER [PDF]
Basrah Journal of Surgery, 2012 A study to compare the efficacy and local toxicity of combining anticancer drugs immunotherapy and chemotherapy (Sequential BCG and mitomycin c) versus mitomycin alone in the treatment of superficial bladder cancer after complete transurethral resection.
Hazim R Akal
doaj +1 more source
Phase I study of everolimus and mitomycin C for patients with metastatic esophagogastric adenocarcinoma [PDF]
, 2013 This study aimed at determining the recommended dose of the mammalian target of rapamycin inhibitor everolimus in combination with mitomycin C (MMC) in patients with previously treated metastatic esophagogastric cancer.
Atmaca, Akin +5 more
core +1 more source
ruvA Mutants that resolve Holliday junctions but do not reverse replication forks [PDF]
, 2008 RuvAB and RuvABC complexes catalyze branch migration and resolution of Holliday junctions (HJs) respectively. In addition to their action in the last steps of homologous recombination, they process HJs made by replication fork reversal, a reaction which ...
A Blastyak +68 more
core +3 more sources
Urological Science, 2019 Objectives: To evaluate the efficacy of instillations with mitomycin C (MMC) or bacillus Calmette–Guérin (BCG) in patients with T1 high-grade bladder cancer (BC).
Li-Wen Chang +10 more
doaj +1 more source
Tissue typing by unidirectional mixed lymphocyte culture. 3. The relationship of in vitro lymphocyte compatibility to renal allograft rejection [PDF]
, 1971 We applied unidirectional MLC test to renal allograft in dogs, and investigated the correlation between the growth rates of MLC reaction and the intensity of rejection of the kidney transplants or the postoperative renal function.
Tsunemitsu, Kensuke
core +1 more source
Genotoxic mixtures and dissimilar action: Concepts for prediction and assessment [PDF]
, 2013 This article has been made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the creative commons Attribution license which permits any use, distribution, and reproduction in any medium, provided ...
A Bouslimi +29 more
core +2 more sources
EO9 (Apaziquone): from the clinic to the laboratory and back again [PDF]
, 2013 EO9 (Apaziquone) is a bioreductive drug that has a chequered history. It underwent clinical trial but failed to show activity in phase II clinical trials when administered i.v.
Aamdal +75 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source