UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells [PDF]
, 2012 The N-end rule pathway is a proteolytic system in which its recognition components (N-recognins) recognize destabilizing N-terminal residues of short-lived proteins as an essential element of specific degrons, called N-degrons.
An, JY +12 more
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Andrology, EarlyView.Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert +10 more
wiley +1 more source
The influence of mitomycin C on the induction of crown-gall tumors [PDF]
, 1969 A.G.M. Gribnau, H. Veldstra
openalex +1 more source
Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: a prospective randomized study. [PDF]
, 2003 PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly increased transport rates compared with passive transport. We performed a prospective study in patients with high risk superficial bladder cancer to assess the efficacy ...
Capelli, G +6 more
core +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To assess the prognosis and determinants of survival after orbital exenteration in patients with conjunctival melanoma (CoM). Methods In a retrospective study, 27 consecutive patients who underwent exenteration for CoM from 2001 to 2023 were included.
David Chetroiu +7 more
wiley +1 more source
Effect of Topical Mitomycin C as an Adjunct to Dilation Therapy in Esophageal Strictures
Pakistan Journal of Medicine and DentistryBackground: The treatment of choice for most esophageal strictures is esophageal dilatation but it has a low success rate. This study was conducted to determine the effect of topical mitomycin C as an adjunct to dilatation therapy in esophageal ...
Zunaira Hameed +3 more
doaj +1 more source
Reversal of gastrointestinal carcinoma-induced immunosuppression and induction of antitumoural immunity by a combination of cyclophosphamide and gene transfer of IL-12 [PDF]
, 2011 Immunotherapy-based strategies for gastrointestinal carcinomas (GIC) have been exploited so far, but these approaches have to face strong mechanisms of immune escape induced by tumours.
Alaniz +69 more
core +1 more source
A study of oral metformin for the intravesical treatment of non‐muscle‐invasive bladder cancer
BJU International, EarlyView.Objectives To evaluate the effect of metformin on non‐muscle‐invasive bladder cancer (NMIBC) marker lesions. Patients and methods A phase II, open‐label, multicentre, marker lesion trial using oral metformin in patients with primary or recurrent, multiple, low‐grade Ta‐T1 NMIBC was conducted. After transurethral resection for histological confirmation,
Jons W. van Hattum +12 more
wiley +1 more source
A randomized placebo controlled trial of Mitomycin - C in surgical outcome of primary endoscopic dacryocystorhinostomy [PDF]
Al Ameen Journal of Medical Sciences, 2013 Objective: To compare the patency of the stoma and relief of epiphora after endoscopic dacrocystorjinostomy (EnDCR) surgery with Mitomycin C and Placebo in cases of chronic dacrocystitis secondary to primary post saccal stenosis.
A.S. Harugop +6 more
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