Results 151 to 160 of about 50,222 (210)

Mitomycin C: a review

Cancer Treatment Reviews, 1976
Summary Preclinical 1. Mitomycin C is an alkylating agent requiring reduction of the quinone to be active. 2. The aziridine ring is essential for the antitumor activity of mitomycin C. 3. The degree of DNA cross-linking and tumor inhibition is proportional to the guanine and cytosine content of the DNA. 4.
S T, Crooke, W T, Bradner
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Mitomycin C.

Cancer chemotherapy and biological response modifiers, 1990
The mitomycins are antitumor antibiotics that are under investigation now for more than 30 years. Mitomycin C (MMC) is the best investigated subtype. It serves as a prototype for drugs with bioreductive alkylation, which is a unique feature of this class. MMC is mainly active under anaerobic circumstances.
J, Den Hartigh, J, Verweij, H M, Pinedo
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Impact of Mitomycin-C Application Time on the Scleral Mitomycin-C Concentration

Journal of Ocular Pharmacology and Therapeutics, 2001
The aim of this study was to determine the effect of varying the application time of Mitomycin-C (MMC) on the scleral concentration of MMC. The sclerae of 14 human donor eyes were used for this study. The episcleral sides of the 4 scleral quadrants of each donor eye were exposed for 0.5, 1, 3 and 5 min to round, 8 mm-diameter sponges soaked with 50 ...
C, Vass, M, Georgopoulos, I, El Menyawi, S, Radda, P, Nimmerrichter   +4 more
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Structure activity relationship for mitomycin C and mitomycin A analogs

Journal of Medicinal Chemistry, 1991
A set of 30 mitomycin C and mitomycin A analogues, including five new compounds, was screened against three different solid human tumor cell lines using the MTT tetrazolium dye assay. A statistically significant correlation among antitumor activity, quinone reduction potential (E1/2), and the logarithm of the partition coefficient (log P) was obtained,
K R, Kunz, B S, Iyengar, R T, Dorr, D S, Alberts, W A, Remers   +4 more
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Mitomycin C (z.B. Mitomycin C „Kyowa“)

2006
aufgrund zahlreicher Berichte uber Nekrosen wird Mitomycin C als gewebsnekrotisierend ...
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Bacteriocidal action of mitomycin C

Biochimica et Biophysica Acta, 1960
Abstract The bacteriocidal action of Mitomycin C has been investigated with respect to its biochemical, genetic and morphological correlates. All findings are consistent with the observation that cells treated with Mitomycin lose DNA, but not RNA or protein, to the surrounding medium.
E, REICH, A J, SHATKIN, E L, TATUM
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Mitomycin C extravasation injuries

Cancer, 1983
Mitomycin C extravasation produces a chronic painful ulceration similar to that of adriamycin. Pain marks the extravasation of this chemotherapeutic agent when it occurs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up.
L C, Argenta, E K, Manders
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Mitomycin-C in Congenital Glaucoma

Ophthalmic Surgery, Lasers and Imaging Retina, 1997
* BACKGROUND AND OBJECTIVE: To evaluate the adjunctive use of mitomycin-C (MMC) during trabeculotomy and trabeculectomy for eyes with highrisk congenital glaucoma. * PATIENTS AND METHODS: A prospective, randomized, double-blind study was performed to compare the effect of a single, 4-minute intraoperative exposure to 0.2 mg/ml (group 1) or 0 ...
H C, Agarwal, N N, Sood, R, Sihota, L, Sanga, S G, Honavar   +4 more
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Potential Toxicity of Mitomycin C

Archives of Ophthalmology, 1991
To the Editor. —Chen et al1and Palmer2recently reported on the use of mitomycin C as adjunct chemotherapy during glaucoma filtration surgery. Both investigations followed similar protocols in which the episclera was soaked with a solution of 0.2 to 0.4 mg/mL of mitomycin C for 5 minutes before creating a sclerostomy.
R J, Derick, L, Pasquale, H A, Quigley, H, Jampel   +3 more
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Mitomycin C extravasation ulcers

Journal of Surgical Oncology, 1985
AbstractIn a four‐year period, eight patients with mitomycin C extravasation ulcers were encountered. Mitomycin C extravasation produces a painful indolent ulcer that does not have any tendency to heal. If extravasation of the drug is recognized, infusion should be stopped immediately, and the site of infusion should be changed.
A K, Khanna, A, Khanna, A K, Asthana, M K, Misra   +3 more
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