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Postoperative Bleb Management with Topical Mitomycin‑C
Journal of Ophthalmic & Vision Research, 2011 Jost B Jonas
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European Journal of Ophthalmology, 2010
Purpose Mitomycin C after photorefractive keratectomy (PRK) is used to reduce the development of haze and regression in higher intended corrections. The aim of this study was to investigate the safety, stability, and efficacy of EpiLASIK with mitomycin C. Methods Fifty eyes of 29 patients underwent EpiLASIK with the Gebauer EpiLift microkeratome.
Chris P. Lohmann +3 more
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Purpose Mitomycin C after photorefractive keratectomy (PRK) is used to reduce the development of haze and regression in higher intended corrections. The aim of this study was to investigate the safety, stability, and efficacy of EpiLASIK with mitomycin C. Methods Fifty eyes of 29 patients underwent EpiLASIK with the Gebauer EpiLift microkeratome.
Chris P. Lohmann +3 more
openaire +3 more sources
Cancer Treatment Reviews, 1976
Summary Preclinical 1. Mitomycin C is an alkylating agent requiring reduction of the quinone to be active. 2. The aziridine ring is essential for the antitumor activity of mitomycin C. 3. The degree of DNA cross-linking and tumor inhibition is proportional to the guanine and cytosine content of the DNA. 4.
William T. Bradner, Stanley T. Crooke
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Summary Preclinical 1. Mitomycin C is an alkylating agent requiring reduction of the quinone to be active. 2. The aziridine ring is essential for the antitumor activity of mitomycin C. 3. The degree of DNA cross-linking and tumor inhibition is proportional to the guanine and cytosine content of the DNA. 4.
William T. Bradner, Stanley T. Crooke
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Bacteriocidal action of mitomycin C
Biochimica et Biophysica Acta, 1960Abstract The bacteriocidal action of Mitomycin C has been investigated with respect to its biochemical, genetic and morphological correlates. All findings are consistent with the observation that cells treated with Mitomycin lose DNA, but not RNA or protein, to the surrounding medium.
Edward L. Tatum, A.J. Shatkin, E. Reich
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Impact of Mitomycin-C Application Time on the Scleral Mitomycin-C Concentration
Journal of Ocular Pharmacology and Therapeutics, 2001The aim of this study was to determine the effect of varying the application time of Mitomycin-C (MMC) on the scleral concentration of MMC. The sclerae of 14 human donor eyes were used for this study. The episcleral sides of the 4 scleral quadrants of each donor eye were exposed for 0.5, 1, 3 and 5 min to round, 8 mm-diameter sponges soaked with 50 ...
S. Radda +4 more
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Mitomycin C extravasation injuries
Cancer, 1983Mitomycin C extravasation produces a chronic painful ulceration similar to that of adriamycin. Pain marks the extravasation of this chemotherapeutic agent when it occurs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up.
Ernest K. Manders, Louis C. Argenta
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Mitomycin-C in Congenital Glaucoma
Ophthalmic Surgery, Lasers and Imaging Retina, 1997* BACKGROUND AND OBJECTIVE: To evaluate the adjunctive use of mitomycin-C (MMC) during trabeculotomy and trabeculectomy for eyes with highrisk congenital glaucoma. * PATIENTS AND METHODS: A prospective, randomized, double-blind study was performed to compare the effect of a single, 4-minute intraoperative exposure to 0.2 mg/ml (group 1) or 0 ...
Lalit Sanga +4 more
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Mitomycin C in dacryocystorhinostomy
Clinical & Experimental Ophthalmology, 2006Igal Leibovitch and Dinesh ...
Leibovitch, I., Selva-Nayagam, D.
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Reductive activation of mitomycin C [PDF]
Biochemistry, 1988 Mitomycin C, an antitumor antibiotic, is known to require reductive activation in order to function as an alkylating agent. In this work reduction has been carried out by using radiolytically produced formate radicals that reduce mitomycin C to its semiquinone in a clean rapid one-electron reaction.
A. J. Swallow, Brigid M Hoey, J. Butler
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Dacryocystorhinostomy with Intraoperative Mitomycin C
Ophthalmology, 1997To observe the effect of intraoperative mitomycin C on the size of the osteotomy site after dacryocystorhinostomy.:A total of 15 eyes of 14 patients diagnosed with primary acquired nasolacrimal duct obstruction were assigned randomly to either a mitomycin C group or a control group.
Jason H.S. Tseng +4 more
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