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Characterization of Liposomes and an Emulsion Containing Mitomycin C or Lipophilic Mitomycin C Prodrugs [PDF]
Journal of Pharmaceutical Sciences, 1986 The characteristics of liposomes and an oil-water emulsion containing either mitomycin C (MMC) or its lipophilic prodrugs were investigated. Prodrugs were incorporated into liposomes and oil droplets of an oil-water emulsion, and this incorporation was dependent on the lipid content of the liposomes and droplets. A good correlation was observed between
Mitsuru Hashida +3 more
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Structure activity relationship for mitomycin C and mitomycin A analogs
Journal of Medicinal Chemistry, 1991A set of 30 mitomycin C and mitomycin A analogues, including five new compounds, was screened against three different solid human tumor cell lines using the MTT tetrazolium dye assay. A statistically significant correlation among antitumor activity, quinone reduction potential (E1/2), and the logarithm of the partition coefficient (log P) was obtained,
Bhashyam S. Iyengar +4 more
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Trabekulektomie mit Mitomycin C [PDF]
Der Ophthalmologe, 2018 Trabeculectomy is the most proven method for the treatment of open angle glaucoma. The long-term results of this method show an 80% success rate in lowering intraocular pressure over 20 years. The surgical technique is demonstrated in detail with the help of a video of the operation and which is available online.
Esther M. Hoffmann, Norbert Pfeiffer
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American Journal of Clinical Oncology, 1984
The clinical spectrum and the pathological findings of renal toxicity in four patients treated with mitomycin-C are described. Our experience and evidence in the literature indicates that the renal impairment appears to be total-dose-related, with most patients developing renal symptoms after receiving at least 60 mg of mitomycin-C.
Richard K. Sibley +3 more
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The clinical spectrum and the pathological findings of renal toxicity in four patients treated with mitomycin-C are described. Our experience and evidence in the literature indicates that the renal impairment appears to be total-dose-related, with most patients developing renal symptoms after receiving at least 60 mg of mitomycin-C.
Richard K. Sibley +3 more
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Journal of the American Chemical Society, 1993
Mitomycin C (1a) is considered to be the protypical bioreductive alkylating agent. Enzymatic reduction leads to activation of the two DNA-bonding sites (C(1) and C(10)) in 1a, permitting the formation of intrahelical interstrand DNA-mitomycin C cross-link adducts.
Suganthini Subramaniam, Harold Kohn
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Mitomycin C (1a) is considered to be the protypical bioreductive alkylating agent. Enzymatic reduction leads to activation of the two DNA-bonding sites (C(1) and C(10)) in 1a, permitting the formation of intrahelical interstrand DNA-mitomycin C cross-link adducts.
Suganthini Subramaniam, Harold Kohn
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Mitomycin C: a clinical update
Cancer Treatment Reviews, 2001Mitomycin C was reviewed in this journal 25 years ago and an update of its clinical usefulness is appropriate. The current review is based on representative publications covering clinical trials performed throughout the world. Single agent activity in each of the major neoplastic diseases has been reassessed when possible and the most important ...
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H2O2 generation during the redox cycle of mitomycin C and DNA-bound mitomycin C
Chemico-Biological Interactions, 1976Reduction of mitomycin C by NaBH4 or by NADPH in the presence of a cell extract followed by exposure to air results in the generation of H2O2. This phenomenon occurs not only with free mitomycin but also with mitomycin irreversibly bound to DNA. In view of these findings, the antibiotic activity of mitomycin was tested in two bacterial systems: a ...
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Delayed hypersensitivity to Mitomycin C
Contact Dermatitis, 2009M. S. Fuentes Vallejo +5 more
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