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Characterization of Liposomes and an Emulsion Containing Mitomycin C or Lipophilic Mitomycin C Prodrugs [PDF]
Journal of Pharmaceutical Sciences, 1986 The characteristics of liposomes and an oil-water emulsion containing either mitomycin C (MMC) or its lipophilic prodrugs were investigated. Prodrugs were incorporated into liposomes and oil droplets of an oil-water emulsion, and this incorporation was dependent on the lipid content of the liposomes and droplets. A good correlation was observed between
Mitsuru Hashida +3 more
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Structure activity relationship for mitomycin C and mitomycin A analogs
Journal of Medicinal Chemistry, 1991A set of 30 mitomycin C and mitomycin A analogues, including five new compounds, was screened against three different solid human tumor cell lines using the MTT tetrazolium dye assay. A statistically significant correlation among antitumor activity, quinone reduction potential (E1/2), and the logarithm of the partition coefficient (log P) was obtained,
Bhashyam S. Iyengar +4 more
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Trabekulektomie mit Mitomycin C [PDF]
Der Ophthalmologe, 2018 Trabeculectomy is the most proven method for the treatment of open angle glaucoma. The long-term results of this method show an 80% success rate in lowering intraocular pressure over 20 years. The surgical technique is demonstrated in detail with the help of a video of the operation and which is available online.
Esther M. Hoffmann, Norbert Pfeiffer
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American Journal of Clinical Oncology, 1984
The clinical spectrum and the pathological findings of renal toxicity in four patients treated with mitomycin-C are described. Our experience and evidence in the literature indicates that the renal impairment appears to be total-dose-related, with most patients developing renal symptoms after receiving at least 60 mg of mitomycin-C.
Richard K. Sibley +3 more
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The clinical spectrum and the pathological findings of renal toxicity in four patients treated with mitomycin-C are described. Our experience and evidence in the literature indicates that the renal impairment appears to be total-dose-related, with most patients developing renal symptoms after receiving at least 60 mg of mitomycin-C.
Richard K. Sibley +3 more
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Mitomycin C in Photorefractive Keratectomy
Journal of Refractive Surgery, 2009Purpose: To evaluate the outcome of primary or retreatment photorefractive keratectomy (PRK) or photo-therapeutic keratectomy (PTK) with mitomycin C (MMC) 0.02% applied prophylactically intraoperatively for the prevention of haze and regression in cases of significant haze and regression after primary PRK, due to previous ...
Ashraf Shalaby +2 more
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Pharmacokinetics of intraperitoneal mitomycin C
Surgical Oncology Clinics of North America, 2003The favorable pharmacokinetics of MMC, used during intraperitoneal chemotherapy, has been reported in several studies [11-19]. A major safety issue in studies using intraperitoneal chemotherapy perfusion is the resulting systemic drug exposure. The AUCplasma is determined by the dose, the clearance, and the fraction absorbed from the peritoneal cavity.
Victor J. Verwaal +2 more
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Mitomycin C (z.B. Mitomycin C „Kyowa“)
2006aufgrund zahlreicher Berichte uber Nekrosen wird Mitomycin C als gewebsnekrotisierend ...
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Bioactivation and Resistance to Mitomycin C
2004Publisher Summary This chapter analyzes the bioactivation and resistance of tumor cells to mitomycin C (MC). MC is a naturally occurring antibiotic that was isolated originally from the microorganism Streptomyces caspitosus . MC exerts its antitumor activity primarily by damaging DNA through both monofunctional and bifunctional alkylations (cross ...
Raymond P. Baumann +3 more
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Intraoperative Mitomycin C in Dacryocystorhinostomy
Ophthalmic Plastic and Reconstructive Surgery, 2001To assess the efficacy of intraoperative mitomycin C (MMC) in external dacryocystorhinostomy (EXT-DCR).Forty-six cases (50 lacrimal drainage systems [LDS]) with nasolacrimal duct obstruction were randomized into three groups. In the control group, a standard EXT-DCR procedure was performed. In the two MMC groups, a piece of cotton soaked with 0.2 mg/ml
Yi-an You, Chun-ting Fang
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Potential Toxicity of Mitomycin C
Archives of Ophthalmology, 1991To the Editor. —Chen et al1and Palmer2recently reported on the use of mitomycin C as adjunct chemotherapy during glaucoma filtration surgery. Both investigations followed similar protocols in which the episclera was soaked with a solution of 0.2 to 0.4 mg/mL of mitomycin C for 5 minutes before creating a sclerostomy.
Robert J. Derick +3 more
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