Results 171 to 180 of about 13,073 (205)
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Journal of Medicinal Chemistry, 1986
AbstractMetallkomplexe wie (I) und (II) aus Mitomycin‐Derivaten sowie (III) werden dargestellt, und ihre Aktivität gegen P388‐Leukä‐ mie wird untersucht.
Bhashyam S. Iyengar+3 more
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AbstractMetallkomplexe wie (I) und (II) aus Mitomycin‐Derivaten sowie (III) werden dargestellt, und ihre Aktivität gegen P388‐Leukä‐ mie wird untersucht.
Bhashyam S. Iyengar+3 more
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Bacteriocidal action of mitomycin C
Biochimica et Biophysica Acta, 1960Abstract The bacteriocidal action of Mitomycin C has been investigated with respect to its biochemical, genetic and morphological correlates. All findings are consistent with the observation that cells treated with Mitomycin lose DNA, but not RNA or protein, to the surrounding medium.
Edward L. Tatum, A.J. Shatkin, E. Reich
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1990
This chapter describes mitomycin syntheses published in the period 1984–1988 plus 1989 literature available by August 1. Mitomycin synthesis was intensively investigated in this period. It is characterized by a considerable variety of strategies and novel chemistry. The most significant accomplishment was an efficient new total synthesis of mitomycin С
Bhashyam S. Iyengar, William A. Remers
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This chapter describes mitomycin syntheses published in the period 1984–1988 plus 1989 literature available by August 1. Mitomycin synthesis was intensively investigated in this period. It is characterized by a considerable variety of strategies and novel chemistry. The most significant accomplishment was an efficient new total synthesis of mitomycin С
Bhashyam S. Iyengar, William A. Remers
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Structural studies of mitomycins. V. Structure of mitomycin H [PDF]
C 15 H 16 N 2 O 4 cristallise dans P2 1 2 1 2 1 avec a=10,929, b=13,446, c=9,686 A, Z=4; affinement jusqu'a R=0,039. Dans ce compose, le groupe carbamate, l'un des groupes fonctionnels caracteristiques de la mitomycine, est remplace par une liaison exocyclique −C=C−.
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Cardiotoxicity of mitomycin A, mitomycin C, and sevenN 7 analogs in vitro
Cancer Chemotherapy and Pharmacology, 1992The alkylating antitumor agents mitomycin A (MMA), mitomycin C (MMC), and seven N7 analogs were compared in terms of their cardiotoxic and antitumor activity in vitro. Neonatal rat-heart myocytes were sensitive to five of the compounds studied, including MMA, 7-dimethylamidinomitosane (BMY-25282), 7-(N-methyl-piperazinyl)-mitosane (RR-194), N7-(4 ...
Nancy G. Shipp+5 more
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Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential
Biochemistry, 1991The mitomycins are a group of antitumor antibiotics that covalently bind to DNA upon reductive activation. Mitomycin A (1b; MA) is more toxic than its clinically useful mitomycin C (1a; MC). The greater toxicity of mitomycin A has been previously attributed to its higher reduction potential.
Roselyn Lipman+4 more
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Structural Studies of Mitomycins. VIII. Mitomycin D Hydrate, C15H18N4O5.1.5H2O
Acta Crystallographica Section C Crystal Structure Communications, 1996The title compound, [1aS]-6-amino-1, 1a,2,4,7,8,8a,8b-octahydro-8a-hydroxy-1,5-dimethyl-4,7-dioxoazirino++ +[2',-3': 3,4]pyrrolo[1,2-a]indol-7-ylmethyl, is a mitomycin derivative, mitomycins being antitumor antibiotics. The O atoms of the quinone ring deviate significantly from the least-squares plane through the quinone ring.
M. Kasai, Noriaki Hirayama, Hitoshi Arai
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Impact of Mitomycin-C Application Time on the Scleral Mitomycin-C Concentration
Journal of Ocular Pharmacology and Therapeutics, 2001The aim of this study was to determine the effect of varying the application time of Mitomycin-C (MMC) on the scleral concentration of MMC. The sclerae of 14 human donor eyes were used for this study. The episcleral sides of the 4 scleral quadrants of each donor eye were exposed for 0.5, 1, 3 and 5 min to round, 8 mm-diameter sponges soaked with 50 ...
S. Radda+4 more
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Journal of the American Chemical Society, 1993
Mitomycin C (1a) is considered to be the protypical bioreductive alkylating agent. Enzymatic reduction leads to activation of the two DNA-bonding sites (C(1) and C(10)) in 1a, permitting the formation of intrahelical interstrand DNA-mitomycin C cross-link adducts.
Suganthini Subramaniam, Harold Kohn
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Mitomycin C (1a) is considered to be the protypical bioreductive alkylating agent. Enzymatic reduction leads to activation of the two DNA-bonding sites (C(1) and C(10)) in 1a, permitting the formation of intrahelical interstrand DNA-mitomycin C cross-link adducts.
Suganthini Subramaniam, Harold Kohn
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1990
The mitomycins are a group of antibiotics, discovered in Japan in the 1950s in fermentation cultures of certain strains of Streptomyces 1. Observation of their significant antitumour activity soon followed and today, one of the drugs, mitomycin C, is widely used in clinical anticancer chemotherapy2.
R. W. Franck, Maria Tomasz
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The mitomycins are a group of antibiotics, discovered in Japan in the 1950s in fermentation cultures of certain strains of Streptomyces 1. Observation of their significant antitumour activity soon followed and today, one of the drugs, mitomycin C, is widely used in clinical anticancer chemotherapy2.
R. W. Franck, Maria Tomasz
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