Results 31 to 40 of about 13,073 (205)

Imatinib decreases germ cell survival and germline stem cell proliferation in rodent testis ex vivo and in vitro

open access: yesAndrology, EarlyView.
Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert   +10 more
wiley   +1 more source

Hyperthermic intraperitoneal chemotherapy after upfront cytoreductive surgery for stage III epithelial ovarian cancer: Follow‐up of long‐term survival

open access: yesActa Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 5, Page 988-997, May 2025.
This study provides further evidence supporting the long‐term efficacy of HIPEC for the primary treatment of advanced ovarian cancer. The PCS‐HIPEC approach achieved superior survival outcomes when optimal cytoreduction was possible. Abstract Introduction The survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) has been well defined at
Ziying Lei   +14 more
wiley   +1 more source

One tube for all: 1‐year outcomes after transition to Paul glaucoma implant at a tertiary centre

open access: yesActa Ophthalmologica, Volume 103, Issue 4, Page 461-468, June 2025.
Abstract Purpose To evaluate the intraocular pressure (IOP) lowering effect and success rate of Paul glaucoma implant (PGI) in refractory glaucoma after changing practice pattern from Ahmed and Baerveldt tubes to PGI. Methods A prospective observational study of the first 50 consecutive PGI surgeries at a single Danish tertiary centre from January 2022
Anne Studsgaard   +2 more
wiley   +1 more source

External validation of current quality care metrics after radical nephroureterectomy

open access: yesBJU International, EarlyView.
Objectives To externally validate the tetrafecta and pentafecta frameworks for assessing the quality of radical nephroureterectomy (RNU) and their correlation with oncological outcomes in patients with localised upper tract urothelial carcinoma (UTUC).
Igor Duquesne   +20 more
wiley   +1 more source

A study of oral metformin for the intravesical treatment of non‐muscle‐invasive bladder cancer

open access: yesBJU International, EarlyView.
Objectives To evaluate the effect of metformin on non‐muscle‐invasive bladder cancer (NMIBC) marker lesions. Patients and methods A phase II, open‐label, multicentre, marker lesion trial using oral metformin in patients with primary or recurrent, multiple, low‐grade Ta‐T1 NMIBC was conducted. After transurethral resection for histological confirmation,
Jons W. van Hattum   +12 more
wiley   +1 more source

Contemporary outcomes in non‐muscle‐invasive bladder cancer: a large European multicentre study

open access: yesBJU International, EarlyView.
Objective To report real‐world rates of non‐muscle‐invasive bladder cancer (NMIBC) recurrence and progression within a European multicentre cohort with detailed information on intravesical instillation courses, as contemporary data on oncological outcomes in NMIBC are limited.
Mattia Longoni   +28 more
wiley   +1 more source

Antibody‐Dependent Cellular Cytotoxicity of iPS Cell‐Derived Natural Killer T Cells by Anti‐GD2 mAb for Neuroblastoma

open access: yesCancer Science, Volume 116, Issue 4, Page 884-896, April 2025.
Unlike invariant natural killer T (iNKT) cells, induced pluripotent stem cell‐derived NKT (iPS‐NKT) cells exert anti‐GD2 monoclonal antibody(mAb)‐mediated antibody‐dependent cell cytotoxicity(ADCC) and exhibit CD16‐dependent cytotoxic activity and produce cytokines.
Katsuhiro Nishimura   +15 more
wiley   +1 more source

Hypertranscription of rDNA Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency

open access: yesCell Proliferation, EarlyView.
Active nucleoli have the capability to release perinuclear heterochromatin, which is a novel event of iPSC reprogramming. ABSTRACT Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless,
Yuchen Sun   +7 more
wiley   +1 more source

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