Results 141 to 150 of about 379,827 (391)
Manipulating Unisexual–Sexual Reproduction Transition to Engineer Genome‐Reconstructed Polyploids
Advanced Science, EarlyView.This study developed an efficient approach to generate genome‐reconstructed polyploids involving unisexual gynogenetic Carassius gibelio, sexual C. auratus, and sexual C. cuvieri. The selected superior clone inherited gynogenesis ability of C. gibelio and herpesvirus resistance of wild C.
Meng Lu +9 more
wiley +1 more source
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Folia Histochemica et Cytobiologica, 2011 MAP kinases of the ERK family play important roles in oocyte maturation, fertilization, and early embryo development. The role of the signaling pathway involving ERK5 MAP kinase during meiotic and mitotic M-phase of the cell cycle is not well known. Here,
Maria A. Ciemerych +3 more
doaj +1 more source
Cellpose+, a Morphological Analysis Tool for Feature Extraction of Stained Cell Images
Advanced Intelligent Discovery, EarlyView.We introduce Cellpose plus, a morphological and geometrical analysis tool for feature extraction of stained cell images built over Cellpose, a state‐of‐the‐art cell segmentation framework. We also introduce a dataset of DAPI and FITC stained cells to which our new method is applied.
Israel A. Huaman +10 more
wiley +1 more source
Augmented Mitotic Cell Count using Field Of Interest Proposal
, 2018 Histopathological prognostication of neoplasia including most tumor grading systems are based upon a number of criteria. Probably the most important is the number of mitotic figures which are most commonly determined as the mitotic count (MC), i.e ...
Aubreville, Marc +3 more
core +1 more source
An epigenetic regulator emerges as microtubule minus-end binding and stabilizing factor in mitosis
Nature Communications, 2015 The evolutionary conserved NSL complex is a prominent epigenetic regulator controlling expression of thousands of genes. Here we uncover a novel function of the NSL complex members in mitosis.
Sylvain Meunier +5 more
semanticscholar +1 more source
AI‐Enhanced Surface‐Enhanced Raman Scattering for Accurate and Sensitive Biomedical Sensing
Advanced Intelligent Discovery, EarlyView.AI‐SERS advances spectral interpretation with greater precision and speed, enhancing molecular detection, biomedical analysis, and imaging. This review explores its essential contributions to biofluid analysis, disease identification, therapeutic agent evaluation, and high‐resolution biomedical imaging, aiding diagnostic decision‐making.
Seungki Lee, Rowoon Park, Ho Sang Jung
wiley +1 more source
Journal of Cell Science, 1989 ABSTRACT Drosophila is an attractive organism in which to study both the rapid rounds of mitosis typical of embryonic development in many species, and the longer cell cycles of diploid tissues later in development. Mutations in genes essential for mitosis in Drosophila may result in lethality in late embryonic, larval or pupal stages of ...
openaire +4 more sources
American Journal of Hematology, EarlyView.ABSTRACT Nodal follicular helper T‐cell (TFH) lymphoma of the angioimmunoblastic (AITL) subtype has a dismal prognosis. Using whole‐exome sequencing (n = 124), transcriptomic (n = 78), and methylation (n = 40) analysis, we identified recurrent mutations in known epigenetic drivers (TET2, DNMT3A, IDH2R172) and novel ones (TET3, KMT2D).
Alyssa Bouska +43 more
wiley +1 more source