Results 141 to 150 of about 163,907 (337)

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

open access: yesAggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang   +3 more
wiley   +1 more source

Mathematical Imaging Methods for Mitosis Analysis in Live-Cell Phase Contrast Microscopy [PDF]

open access: yesarXiv, 2016
In this paper we propose a workflow to detect and track mitotic cells in time-lapse microscopy image sequences. In order to avoid the requirement for cell lines expressing fluorescent markers and the associated phototoxicity, phase contrast microscopy is often preferred over fluorescence microscopy in live-cell imaging.
arxiv  

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

open access: yesHepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai   +29 more
wiley   +1 more source

Mitosis: Transparently Self-Replicating Page-Tables for Large-Memory Machines [PDF]

open access: yesarXiv, 2019
Multi-socket machines with 1-100 TBs of physical memory are becoming prevalent. Applications running on multi-socket machines suffer non-uniform bandwidth and latency when accessing physical memory. Decades of research have focused on data allocation and placement policies in NUMA settings, but there have been no studies on the question of how to place
arxiv  

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

open access: yesHepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam   +10 more
wiley   +1 more source

Dosage‐dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses

open access: yesThe Anatomical Record, EarlyView.
Abstract Craniosynostosis is a common yet complex birth defect, characterized by premature fusion of the cranial sutures that can be syndromic or nonsyndromic. With over 180 syndromic associations, reaching genetic diagnoses and understanding variations in underlying cellular mechanisms remains a challenge.
Heather A. Richbourg   +9 more
wiley   +1 more source

Enigmatic Morpho Insight: Mitosis At A Glance

open access: yesJournal of Oral and Maxillofacial Pathology, 2014
NEOPLASM is an abnormal and un-coordinated growth of tissue, which is categorized by WHO (World Health Organization) as benign tumors, in-situ tumors, malignant tumors, and neoplasms of uncertain or unknown behavior.[1] Cancer is a malignant tumor featuring abnormal cell growth and cellular division resulting in excessive cellular proliferation ...
openaire   +4 more sources

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers

open access: yesThe Anatomical Record, EarlyView.
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Scott C. Miller
wiley   +1 more source

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