Results 141 to 150 of about 365,471 (413)

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia   +19 more
wiley   +1 more source

Pds5A and Pds5B Display Non-redundant Functions in Mitosis and Their Loss Triggers Chk1 Activation

Frontiers in Cell and Developmental Biology, 2020
BackgroundPds5 is an abundant HEAT-repeat-containing protein that binds to cohesin and mediates sister chromatid cohesion. In vertebrates, Pds5A and Pds5B are known to protect DNA replication fork, as their loss leads to DNA damage.
Naif Al-Jomah, Naif Al-Jomah, Lubinda Mukololo, Lubinda Mukololo, Awais Anjum, Awais Anjum, Mohammed Al Madadha, Mohammed Al Madadha, Raj Patel   +8 more
doaj   +1 more source

From START to FINISH : the influence of osmotic stress on the cell cycle [PDF]

, 2013
Peer reviewedPublisher ...
A Amon, A Bardin, A Ciliberto, A Goldbeter, A Skirycz, Alistair J. P. Brown, C Dahmann, C Epstein, Celso Grebogi, CL Theesfeld, D Lew, D Lew, D McCollum, D Morgan, Despoina Kaloriti, DJ Lew, E Nigg, E Schwob, E Schwob, E Traverso, Elahe Radmaneshfar, F Cross, F Cross, F Stegmeier, F Stegmeier, G Bellí, G Yaakov, H Claeys, H Saito, J Brewster, J Clotet, J McMillan, JL Burton, K Chen, K Chen, KJ Simpson-Lavy, L Dirick, M Adrover, M Alexander, M Barberis, M Barberis, M Barberis, M Gustin, M Mendenhall, M Tyers, M. Carmen Romano, Marco Thiel, Michael C. Gustin, Michael Polymenis, N Grandin, Neil A. R. Gow, P Nash, P Nurse, R Sia, R Sia, R Venta, R Verma, RN Booher, S Chandrasekaran, S Ghaemmaghami, S Jaspersen, S Jensen, S Piatti, T Su, U Surana, V Nguyen, V Reiser, W Zachariae, X Escoté, Z Zi   +69 more
core   +3 more sources

Sperm‐Derived CircRNA‐1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta‐miR‐2478‐L‐2

Advanced Science, EarlyView.
Sperm‐derived circRNA‐1572 competitively binds to bta‐miR‐2478‐L‐2 through a “sponge” mechanism to regulate cyclin B2 (CCNB2) expression, thereby modulating the distribution of fibrous actin (F‐actin) in early pig embryos, ensuring proper chromosome segregation during mitosis, and facilitating normal embryo cleavage and zygotic genome activation.
Yanfang Wu, Yaochang Wei, Yuelin Li, Yiming Dou, YongQiang Yang, Hanghang Liu, Xiaoyan Wang, Zheng Wang, Jianmin Su, Yong Zhang, Yongsheng Wang   +10 more
wiley   +1 more source

Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos

Frontiers in Cell and Developmental Biology
To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may ...
Hideko Utsumi, Hideko Utsumi, Taijiro Yabe, Taijiro Yabe, Taijiro Yabe, Sumito Koshida, Sumito Koshida, Sumito Koshida, Akira Yamashita, Akira Yamashita, Akira Yamashita, Shinji Takada, Shinji Takada, Shinji Takada   +13 more
doaj   +1 more source

Cell cycle regulation of a Xenopus Wee1-like kinase [PDF]

, 1995
Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr- 15 in a cyclin-dependent manner.
Coleman, Thomas R., Dunphy, William G., Mueller, Paul R.   +2 more
core  

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Water droplet excess free energy determined by cluster mitosis using guided molecular dynamics [PDF]

, 2015
Atmospheric aerosols play a vital role in affecting climate by influencing the properties and lifetimes of clouds and precipitation. Understanding the underlying microscopic mechanisms involved in the nucleation of aerosol droplets from the vapour phase ...
Ford, IJ, Hunt, PA, Jackson, G, Lau, GV, Muller, EA   +4 more
core   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

Replication Stress in Mammalian Cells and Its Consequences for Mitosis

Genes, 2015
The faithful transmission of genetic information to daughter cells is central to maintaining genomic stability and relies on the accurate and complete duplication of genetic material during each cell cycle.
C. Gelot, I. Magdalou, B. Lopez
semanticscholar   +1 more source