Results 281 to 290 of about 329,783 (340)

Mitotic entry is controlled by the plant-specific phosphatase BSL1 and cyclin-dependent kinase B. [PDF]

Nat Plants
Tulin F, Aizezi Y, Reyes AV, Fujieda Y, Grossman A, Xu SL, Onishi M, Assaad FF, Wang ZY.   +8 more
europepmc   +1 more source

MASTL Promotes Hepatocellular Carcinoma Progression and Paclitaxel Resistance Through Mitotic Catastrophe

Cancer Science, EarlyView.
MASTL drives hepatocellular carcinoma (HCC) progression and paclitaxel resistance by triggering mitotic catastrophe. Depletion of MASTL induces DNA damage and promotes mitotic catastrophe, leading to cell death in HCC. MASTL‐mediated mitotic catastrophe depends on PP2A‐B55α activity, suggesting a novel therapeutic target for overcoming chemotherapy ...
Ke Wang, Ziwei Fu, Chuan Xiong, Jing Zhang, Qiang Luo   +4 more
wiley   +1 more source

Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment. [PDF]

Commun Biol
Sharma S, Berger H, Meyer T, Teruel MN.
europepmc   +1 more source

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, EarlyView.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Safeguarding genome integrity: Polo-like kinase Cdc5 and phosphatase Cdc14 orchestrate Topoisomerase II-mediated catenane resolution in mitosis. [PDF]

Nucleic Acids Res
Massari LF, Finardi A, Visintin C, Calabrese E, Dondi A, Visintin R.   +5 more
europepmc   +1 more source

LncRNA H19‐Encoded Micropeptide altH19 Promotes DNA Replication and Mitosis in Myeloma Cells by Enhancing the Phosphorylation of CDK2 at Threonine 160

Cell Proliferation, EarlyView.
The micropeptide altH19 interacts with phosphorylated CDK2 (p‐CDK2), subsequently activating CDK2 phosphorylation. This enhances the downstream E2F1 target gene RB activity, which accelerates DNA replication, ultimately leading to rapid myeloma cell mitosis and proliferation.
Yaxin Zhang, Wenjing Li, Xu Cao, Jiwei Mao, Xiaodan Zhou, Linlin Liu, Ruosi Yao   +6 more
wiley   +1 more source

Regional Conservation and Transcriptional Regulation of Tumor-Associated Genes by macroH2A1 Deposition in Mammalian Cells. [PDF]

Biomolecules
Deng Y, Xu Z, Zhang L, Ye B, Shao Z, Li X.   +5 more
europepmc   +1 more source

FAM20A Deficiency Drives Transcriptomic Dysregulation and Functional Impairment in Gingival Fibroblasts

Cell Proliferation, EarlyView.
FAM20A variants cause AI1G, marked by enamel defects, gingival overgrowth and ectopic calcifications. RNA sequencing of patient‐derived gingival fibroblasts showed dysregulated genes in adhesion, proliferation and signalling pathways. Functional assays revealed increased cell proliferation, impaired ECM interactions and osteogenesis, suggesting FAM20A ...
Kanokwan Sriwattanapong, Sermporn Thaweesapphithak, Chompak Khamwachirapitak, Pannagorn Sae‐ear, Sasiprapa Prommanee, Noppadol Sa‐Ard‐Iam, Suphalak Phothichailert, Han Sung Jung, Vorasuk Shotelersuk, Thantrira Porntaveetus   +9 more
wiley   +1 more source

CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation. [PDF]

EMBO Rep
Liu M, Cheng A, You W, Wu J, Dai C, Wang T, Wu Y, Zhong F, Shi J, Du Y, Hou Z, Gao P, Ruan K, Yang Y, Zhao Y, Zhang K, Yang Z, Guo J.   +17 more
europepmc   +1 more source