Results 181 to 190 of about 133,809 (280)

Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development

Cancer Science, EarlyView.
Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura, Minji Jo, Motoko Takahashi, Toru Hirota   +3 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, Volume 59, Issue 6, June 2026.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Tui: A Multigenerational and Expert-Correctable Tracker for Cellular Dynamics. [PDF]

Comput Struct Biotechnol J
Chang IM, Tsai HF.
europepmc   +1 more source

Nucleolar material in mitosis: ultrastructural and specific detection

, 1975
Trabajo presentado en el Fourth European Nucleolar Workshop, celebrado en Varna (Bulgaria) en 1975.
openaire   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

A Unified Deep Learning Framework for Instance Segmentation Across Diverse Cytological Stains

Cytopathology, EarlyView.
Transformer‐based unified cytology segmentation across Papanicolaou, Feulgen and AgNOR achieves stain‐invariant performance. Mask2Former maximises boundary precision (AP75) on the combined dataset, enabling one model to replace multiple stain‐specific deployments without accuracy loss while simplifying clinical integration.
Luís Otávio Santos, Rodrigo de Paula E. Silva Ribeiro, Bibiana Quatrin Tiellet, Laura Maria Effting Silva, Fabiana Botelho de Miranda Onofre, Alexandre Sherlley Casimiro Onofre, Aldo von Wangenheim   +6 more
wiley   +1 more source

AI‐Assisted Fungal Detection in Dermatopathology: A Study on Accuracy, Efficiency, and Usability

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives AI‐based image analysis is increasingly applied in pathology. Excluding fungal elements in PAS‐stained skin sections is labor‐intensive and well suited for AI assistance. While fungal detection in nails has been studied, skin‐biopsy applications and real‐world benefit remain limited.
Paul Schmidle, Tobias Lang, Sebastian Springenberg, Diego Calvopiña, Theresa Köhler, Valentina Getova, Ana‐Maria Gebing, Sonja Hetzer, Johanna Pierrone, Valentin Aebischer, Dieter Metze, Almut Böer‐Auer, Stephan Alexander Braun   +12 more
wiley   +1 more source

A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1-Driven Raf-ERK Pathway Activation Promotes Cardiomyocyte Mitosis. [PDF]

MedComm (2020)
Cao C, Ma B, Zhang J, Yang L, Liu Z, Li H, Song J, Zhang K, Li L, Fu J, Liu J.   +10 more
europepmc   +1 more source

Neuroimmune alterations and nociceptive behavior in oral carcinogenesis in rats

European Journal of Oral Sciences, EarlyView.
Abstract Oral cancer pain is a frequent and debilitating symptom associated with tumor progression. Although neuronal mechanisms have been extensively studied, the role of immune and glial cells in the trigeminal nociceptive pathway remains poorly understood.
Joana Maria dos Santos Alves, Luiza Clertiani Vieira Alves, Vitória Tavares Bessa, Anamaria Falcão Pereira, Roberto César Pereira Lima Júnior, Mariana Lima Vale, Karuza Maria Alves Pereira, Delane Viana Gondim   +7 more
wiley   +1 more source

Interface-Sensitive Epi-Coherent Anti-Stokes Raman Scattering Microscopy for Imaging Cell Adhesion Dynamics. [PDF]

Anal Chem
Zhou M, Dong B, Lukov L, Ma S, He X, Zafarjafarzadeh N, Zhang C.   +6 more
europepmc   +1 more source