Results 61 to 70 of about 107 (106)
Experimental Physiology, Volume 110, Issue 5, Page 694-707, 1 May 2025.Abstract Heart failure with preserved ejection fraction (HFpEF) is frequently attributed etiologically to an underlying left ventricular (LV) diastolic dysfunction, although its pathophysiology is far more complex and can exhibit significant variations among patients. This review endeavours to systematically unravel the pathophysiological heterogeneity
Paula Sagmeister +8 more
wiley +1 more source
Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant
American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.ABSTRACT P21‐activated kinase 2 (PAK2) is a serine/threonine kinase essential for a variety of cellular processes including signal transduction, cellular survival, proliferation, and migration. A recent report proposed monoallelic PAK2 variants cause Knobloch syndrome type 2 (KNO2)—a developmental disorder primarily characterized by ocular anomalies ...
Elizabeth A. Werren +10 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 2335-2346, June 2025.Abstract Aims Although predominant in routine practice, non‐ischaemic cardiogenic shock (NICS) remains underrepresented in past studies, mainly focused on ischaemic cardiogenic shock (CS). This study aims to describe the current NICS picture and define its independent correlates of short‐ and long‐term outcomes.
Miloud Cherbi +20 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 2321-2334, June 2025.Abstract Aims No curative treatment is available for RASopathy‐associated childhood‐onset hypertrophic cardiomyopathy (RAS‐CM). Preclinical data and individual reports suggest a beneficial effect of small molecules targeting the RAS–mitogen‐activated protein (MAP) kinase (MAPK) pathway in severely affected RAS‐CM patients.
Jules Hamers +11 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 1883-1892, June 2025.Abstract Aims Ischaemic mitral regurgitation (MR) is a dynamic condition influenced by global and regional left ventricular remodelling as well as mitral valvular deformation. Exercise testing plays a substantial role in assessing the haemodynamic relevance of MR and is recommended by current guidelines.
Maximilian Spieker +14 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 1956-1964, June 2025.Abstract Aims Despite receiving guideline‐directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH‐LHD) experience higher mortality and hospitalization rates than the general HF population.
Marcin Ufnal +17 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 2034-2046, June 2025.Abstract Aims Describe patient characteristics, treatment patterns, clinical outcomes, healthcare resource utilization (HCRU) and medical costs associated with patients who were diagnosed with obstructive hypertrophic cardiomyopathy (HCM) in clinical practice in England.
Faizel Osman +9 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 1620-1629, June 2025.Abstract Aims Patients hospitalized with acute heart failure (AHF) treated with a 7 day prednisone course in the CORTAHF pilot trial had a greater improvement in health‐related quality of life (QoL) at Day 7 in both the overall population and in patients with baseline interleukin 6 > 13 pg/mL.
Matteo Pagnesi +21 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 2177-2189, June 2025.Abstract Aims A novel marker left atrioventricular coupling index (LACI) has been proved to be associated with cardiovascular events in patients without history of cardiovascular disease. However, the studies on cardiac magnetic resonance‐derived LACI in hypertrophic cardiomyopathy (HCM) patients are limited, and the prognostic value of LACI has still ...
Jinyang Wen +10 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 3, Page 2267-2277, June 2025.Abstract Background Atrial secondary mitral valve regurgitation (ASMR) is a distinct anatomical subset of secondary mitral regurgitation (SMR). Evidence of the effect of transcatheter edge‐to‐edge repair (TEER) on left atrial (LA) anatomy and function, especially reverse remodelling (LARR), is still sparse.
Aniela Petrescu +10 more
wiley +1 more source