Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Resilience-oriented optimization of hospital microgrids with critical load support using ESS and PV under grid outage conditions. [PDF]
Sci RepNazartalab P, Alavi-Rad H.
europepmc +1 more source
Energy Criticality Avoidance-Based Delay Minimization Ant Colony Algorithm for Task Assignment in Mobile-Server-Assisted Mobile Edge Computing. [PDF]
Sensors (Basel), 2023 Huang X, Lei B, Ji G, Zhang B.
europepmc +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
SLA aware deep reinforcement learning for adaptive EdgeCloud task scheduling. [PDF]
Sci RepYamsani N, P CR.
europepmc +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Variable-Condition Operational Optimization of Oil and Gas Gathering Systems Considering Renewable Energy Accommodation: A Comprehensive Review and Future Perspectives. [PDF]
ACS OmegaWang S, Wang W.
europepmc +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
Robust topology and dispatch optimization for renewable distribution networks with electric vehicle mobility uncertainty. [PDF]
Sci RepXu L, Jiang J, Hu S, Wang T, Dong J.
europepmc +1 more source
Improving the Scheduling of Certifiable Mixed-Criticality Sporadic Task Systems
, 2013 An increasing trend in embedded system design is to integrate components with different levels of criticality into a shared hardware platform for better cost and power efficiency.
Ekberg, Pontus +3 more
core