Results 201 to 210 of about 3,283 (262)

From Evidence to Requirements: The Implementation-Aware Target Product Profile (iTPP) for Specifying Mobile Outreach Cancer Testing Pathways

Kierkegaard P, Su B, Moghul M, Cahill D, James ND.   +4 more
europepmc   +1 more source

The Dialogic Health Systems Research Framework (DHSRF): A tool for facilitating self-criticality, researcher interactions and knowledge management in Health Systems Research & Policy Studies. [PDF]

PLOS Glob Public Health
Priya R, Das S, Kuriakose LM, Shukla M, Sarkar A, Dumka N, Hannah E, Basheer N, Kotwal A.   +8 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Critical nodes identification and cascading failure mitigation strategies in multi-layer coupled networks of interdependent critical infrastructures. [PDF]

Sci Rep
Liu J, Yang F, Jiang M, Li H.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Comprehensive resistome and antibiotic profiling in wastewater and biosolids: a case study. [PDF]

Front Microbiol
Lara-Moreno A, Madrid F, Rubio-Bellido M, Borsetto C, Nurmi W, Alonso E, Santos JL, Villaverde J.   +7 more
europepmc   +1 more source

Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex. [PDF]

J Neural Eng
Coventry BS, Luu CP, Bartlett EL.
europepmc   +1 more source

The Connectome Modulates Critical Brain Dynamics Across Local and Global Scales

Rabuffo G, Bozzo P, Nguyen B, Depannemaecker D, Pompili MN, Gollo LL, Fukai T, Sorrentino P, Dalla Porta L.   +8 more
europepmc   +1 more source

Unveiling Cortical Criticality Changes along the Prodromal to the Overt Continuum of Alpha-Synucleinopathy. [PDF]

J Neurosci
Roascio M, Wang SH, Myrov V, Siebenhühner F, Trò R, Mattioli P, Famà F, Morbelli SD, Pardini M, Orso B, Palva JM, Arnaldi D, Arnulfo G.   +12 more
europepmc   +1 more source

Canalization as a stabilizing principle of gene regulatory networks: a discrete dynamical systems perspective. [PDF]

NPJ Syst Biol Appl
Kadelka C.
europepmc   +1 more source