Results 111 to 120 of about 3,064,383 (240)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Serving to win: exploring serve-reception effectiveness in high-level male and female sitting volleyball players

Frontiers in Sports and Active Living
IntroductionThis study was planned to assess the association between serve efficacy and match outcome, and to investigate which factors are associated with serve efficacy in high-level male and female Sitting Volleyball players.MethodsThe study sample ...
Valentina Cavedon, Marco Sandri, Paola Zuccolotto, Caterina Biasiolo, Carlo Zancanaro, Chiara Milanese   +5 more
doaj   +1 more source

The Utility of Mixed Effects Models in the Evaluation of Complex Genomic Traits In Vitro. [PDF]

Drug Metab Dispos, 2023
Alade N, Nath A, Isoherranen N, Thummel KE.   +3 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Multi-environment performance analysis identifies more productive and widely adapted chicken breeds for smallholder farmers

Frontiers in Sustainable Food Systems
Smallholder chicken production system is dominant in tropical developing countries and it contributes significantly to the livelihoods of farmers. Performance of flocks is often too low to meet growing demands for meat and eggs.
Fasil Getachew Kebede, Fasil Getachew Kebede, Fasil Getachew Kebede, Hans Komen, Tadelle Dessie, Olivier Hanotte, Olivier Hanotte, Steve Kemp, Setegn Worku Alemu, Setegn Worku Alemu, John W. M. Bastiaansen   +10 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Bayesian Models Are More Sensitive than Frequentist Models in Identifying Differences in Small Datasets Comprising Phonetic Data

Stats
While many studies have previously conducted direct comparisons between results obtained from frequentist and Bayesian models, our research introduces a novel perspective by examining these models in the context of a small dataset comprising phonetic ...
Georgios P. Georgiou
doaj   +1 more source

Smoothed simulated pseudo-maximum likelihood estimation for nonlinear mixed effects models with censored responses. [PDF]

Stat Methods Med Res, 2023
Song Y, Wang R.
europepmc   +1 more source