Results 91 to 100 of about 3,064,383 (240)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Predicting Heavy Metal and Nutrient Availability in Agricultural Soils Under Climatic Variability Using Regression and Mixed-Effects Models

Land
It is well known that physico-chemical soil parameters can influence, or even determine, the concentrations of heavy metals in soil. Moreover, in recent decades, there has been growing concern about the role of climatic variables such as temperature ...
Vassilios Diakoloukas, Georgios Koutopoulis, Sotiria G. Papadimou, Marios-Efstathios Spiliotopoulos, Evangelia E. Golia   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Provenance-Specific Height–Diameter Modeling for Chinese Fir: A Clustered Mixed-Effects Approach

Biology
Chinese fir is the predominant afforestation species in southern China, exhibiting distinct provenances due to long-term climatic adaptation. This study utilized data from four surveys conducted at different ages in a provenance trial forest at Zhangping
Xiangrong Wu, Yuhan Wang, Yanjuan Lyu, Wanrong Chen, Ming Li, Shuaichao Sun   +5 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Modeling of antibody waning after heterologous boosting with Ad5-nCoV in individuals primed with two-dose CoronaVac previously

Human Vaccines & Immunotherapeutics
Heterologous boosting with aerosolized or intramuscular Ad5-nCoV following a two-dose CoronaVac prime has been shown to induce higher antibody levels than a homologous CoronaVac booster. However, no specific modeling has been reported to characterize the
Ruifan Shen, Lairun Jin, Xinglu Peng, Yuyuan Zhou, Pengfei Jin, Jingxin Li   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

IMF arrangements, politics and the timing of stabilizations [PDF]

This paper analyses the effects of International Monetary Fund (IMF) arrangements on the timing of inflation stabilization programs. Essentially, we test the hypothesis that IMF aid accelerates stabilization using probit and proportional hazards models ...
Francisco José Veiga
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Model selection in Bayesian framework to identify the best WorldView-2 based vegetation index in predicting green biomass of salt marshes in the northern Gulf of Mexico

GIScience & Remote Sensing, 2018
Coastal wetlands are among the most productive ecosystems globally but have experienced dramatic degradation and loss within the past several decades. Vegetation biomass of coastal wetlands is not only the key component of blue carbon storage but also ...
Wei Wu, Matthew Bethel, Deepak R. Mishra, Tyler Hardy   +3 more
doaj   +1 more source