Results 31 to 40 of about 105,111 (265)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hydraulic performance and flow resistance tests of various hydraulic parts for optimal design of a reactor coolant pump for a small modular reactor

open access: yesNuclear Engineering and Technology, 2023
Hydraulic performance and flow resistance tests were performed to confirm the main parameters of the hydraulic instrumentation that can affect the pump performance of the reactor coolant pump.
Byeonggeon Bae, Jaeho Jung, Je Yong Yu
doaj   +1 more source

The design of a circulating water pump for a power plant based on CFD [PDF]

open access: yesE3S Web of Conferences, 2020
Because of the head and efficiency of the circulating water pump in a power plant could not satisfy application requirement, the guide vane and impeller were optimized according to the CFD method.
Chen Wanbo
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

On Improvement of Characteristic Instability and Internal Flow in Mixed Flow Pumps

open access: yesJournal of Fluid Science and Technology, 2008
The difference of pump characteristics between two kinds of mixed flow pumps with low specific speed of 350 (min-1, m3/min, m), which have the same impeller and the different diffuser vanes, is presented in the present paper.
Masahiro MIYABE   +4 more
doaj   +1 more source

Improving the Energy Efficiency of the Use of Oil Jet Pumps

open access: yesИзвестия высших учебных заведений и энергетических объединенний СНГ: Энергетика, 2022
The substantiation of the choice of design parameters characterizing the mutual orientation of the mixed flows and the ratio of the geometric dimensions of the elements of the flow path of the jet pump that provide an increase in the energy ...
D. A. Panevnyk
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Hydrodynamic performance enhancement of a mixed-flow pump

open access: yesIOP Conference Series: Earth and Environmental Science, 2012
This paper presents an optimization procedure based on a radial basis neural network surrogate model for design of a vaned diffuser in a mixed-flow pump. Numerical analysis of fluid flow in a mixed-flow pump has been carried out by solving three-dimensional Reynolds-averaged Navier-Stokes equations with the shear stress transport turbulence model.
J H Kim, K Y Kim
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

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