Results 51 to 60 of about 108,792 (260)

Hydrodynamic Characteristic Analysis and NSGA-II Optimization of a Vacuum Fish Pump

Journal of Marine Science and Engineering, 2023
The fish pump is an important piece of power equipment for aquaculture, especially for deep-sea engineering vessels and cage culture. Fish pump research focuses on reducing fish body damage, improving survival rates, and increasing fish lifting ...
Yang Hong, Ye Zhu, Chenglin Zhang, Meng Yang, Tao Jiang   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Inlet and Outlet Flow of a Mixed-Flow Pump.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B, 1992
In order to establish a performance prediction method of mixed-flow pumps in all flow ranges, the inlet and outlet flow characteristics are measured and the characteristics of inlet reverse flow in low flow range are discussed, as it exerts remarkable influence on the performance.
JIANG, Jie, KUROKAWA, Junichi
openaire   +2 more sources

Numerical study on the cavitation phenomenon for the head drop and unsteady bubble patterns with a difference in the incidence angle of a mixed-flow pump

Advances in Mechanical Engineering, 2020
In this study, two types of mixed-flow pump models exhibiting different suction performances were investigated to understand the cavitation characteristics of head drop gradients due to the decrease in inlet pressure.
Yong-In Kim, Hyeon-Mo Yang, Jun-Won Suh, Sung Kim, Kyoung-Yong Lee, Young-Seok Choi   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Multi-condition optimization and experimental study of impeller blades in a mixed-flow pump

Advances in Mechanical Engineering, 2016
On the basis of design of experiment and numerical simulation, a reliable optimization method for blades of a mixed-flow pump is proposed with the maximum weighted average efficiency at multi-conditions as optimum objective. First, the performance of the
Houlin Liu, Xinxiang Chen, Kai Wang, Minggao Tan, Xiaohua Zhou   +4 more
doaj   +1 more source

Experimental Study of Pressure Pulsation in a Mixed-Flow Pump with Different Tip Clearances Based on Wavelet Analysis

Shock and Vibration, 2020
In order to investigate the effect of various impeller tip clearances on the pressure pulsation in a mixed-flow pump, the energy performance test and pressure pulsation experiment of a mixed-flow pump with different tip clearances are studied ...
Leilei Ji, Wei Li, Weidong Shi, Ling Zhou, Ramesh Agarwal   +4 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source