Results 101 to 110 of about 3,788,176 (279)
British Journal of Clinical Pharmacology, EarlyView.This study provides the first open‐source tool to implement the complete TEN‐SPIDERS framework in linked datasets for the determination of the PDC for medication adherence. The TEN‐SPIDERS tool enables transparent, reproducible medication adherence research through automated reporting of all calculation parameters and flexible customization options ...
Adam C. Livori +8 more
wiley +1 more source
Global optimality conditions for mixed integer nonlinear programming problems
四川大学学报. 自然科学版, 2017 In recent years, the application of mixed integer nonlinear programming problem has been extremely active and very extensive. In this paper, some necessary conditions for a given global minimizer applied to mixed integer nonlinear programming problem ...
QUAN Jing, LI Guo-Quan
doaj
Why Methods for Optimization Problems with Time-Consuming Function Evaluations and Integer Variables Should Use Global Approximation Models [PDF]
This paper advocates the use of methods based on global approximation models for optimization problems with time-consuming function evaluations and integer variables.We show that methods based on local approximations may lead to the integer rounding of ...
Brekelmans, R.C.M. +4 more
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British Journal of Clinical Pharmacology, EarlyView.Aims Cytochrome P450 2C19 (CYP2C19) genotype testing is recommended to guide antiplatelet selection after ischaemic stroke and transient ischaemic attack. CYP2C19 also metabolizes several commonly prescribed non‐antiplatelet drugs. We aimed to quantify exposure to CYP2C19‐metabolized drugs in stroke patients at hospital discharge and during ...
Cleodie C. Swire +3 more
wiley +1 more source
Real‐time biosensing of Parkinson's disease biomarkers via NIR‐activated upconversion nanoparticles
BMEMat, EarlyView.Schematic illustration of the luminescence resonance energy transfer‐driven core‐shell‐shell UCNPs (cssUCNPs@Fluo4) nanoprobe for simultaneous monitoring of Ca²⁺‐temperature dynamics in Parkinson's disease models. Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with incompletely understood pathophysiology, necessitating ...
Jialin Liu +9 more
wiley +1 more source
InformationWe analyzed a special class of graph traversal problems, where the distances are stochastic, and the agent is restricted to take a limited range in one go.
Tamás Kegyes +3 more
doaj +1 more source
Reformulation and decomposition of integer programs [PDF]
In this survey we examine ways to reformulate integer and mixed integer programs. Typically, but not exclusively, one reformulates so as to obtain stronger linear programming relaxations, and hence better bounds for use in a branch-and-bound based ...
WOLSEY , Laurence +1 more
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Business Strategy and the Environment, EarlyView.ABSTRACT This study demonstrates how a profitable, lean, and environmentally responsible e‐waste reverse logistics system can be designed using integrated Operations Research (OR) techniques. Addressing the growing urgency of responsible consumption (UN SDG 12) and the projected rise of the e‐waste sector to USD 137.60 billion by 2029, the research ...
Sheeba Pathak, Hajar Fatorachian
wiley +1 more source
A multi-step mixed integer programming heuristic for warehouse layout optimization
Supply Chain AnalyticsWarehouse layout optimization is critical to inventory and logistics management in organizations. In many instances, limited warehouse space is a constraint and a barrier to expanding operations and increasing demand.
Sanjaya Mayadunne +2 more
doaj +1 more source
Advances in Mechanical Engineering, 2013 Engineering optimization problems usually contain various constraints and mixed integer-discrete-continuous types of design variables. We propose an efficient particle swarm optimization (PSO) algorithm for such problems.
Semin Chun +2 more
doaj +1 more source