Results 71 to 80 of about 15,896,803 (284)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
NCRM podcast: The 'Thing-ness' problem of mixed methods research
, 2014 Is mixed methods research a turbulent environment and is innovation being stifled by an overly tightly bound concept of what it is? Sharlene Hesse-Biber, professor in the Sociology Department of Boston College thinks so.
Hesse-Biber, Sharlene
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, 2011 Mixed methods research has emerged as a credible alternative to unitary research approaches. The authors show how a combination of a triangulation convergence model with a triangulation multilevel model was used to research an aspiring school principal ...
Eileen Piggot-Irvine +3 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Laura Camfield on undertaking cross-national mixed methods research [PDF]
, 2023 In this episode of the Methods podcast, host Catherine McDonald talks to Laura Camfield, Professor of Development Research and Evaluation in the School of International Development at the University of East Anglia.
McDonald, Catherine
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Computer-assisted integration of mixed methods data sources and analyses
, 2010 New tools within analysis software, developed in response to the growing interest in mixed methods research, facilitate and extend possibilities for working with mixed data types and analysis methods.
Bazeley, Pat (R13373), Pat Bazeley
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Mixed methods practice in operational research: designs for wicked problems
, 2023 In operational research (OR), practitioners model and analyse real-world issues, and support organizational and policy decision-making. Traditionally, they use quantitative methods, such as optimization, simulation, and statistical analysis.
Christie, Jane S.
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Mixed Methods in Suicide Research
, 2021 Mixed methods offer a valuable third paradigm in suicide research that can address the limitations of quantitative and qualitative research methods.
Ross, Victoria, Kolves, Kairi
core
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source