Results 161 to 170 of about 5,761,259 (326)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Mixed-mode control of multiphase interleaved parallel circuit for pulsed laser diode driving. [PDF]

Sci Rep
Wu B, Liu J, Zhao H, Guo J, Liu Z.
europepmc   +1 more source

A boundary element alternating method for two-dimensional mixed-mode fracture problems [PDF]

A boundary element alternating method, denoted herein as BEAM, is presented for two dimensional fracture problems. This is an iterative method which alternates between two solutions.
Krishnamurthy, T., Raju, I. S.
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Nickel-containing 4,4'-biphenol mixed-mode stationary phase for the separation of polyaromatic compounds, benzene derivatives and nucleotides. [PDF]

RSC Adv
Hira, Ali F, Waqar M, Cheong WJ, Munazzah, AlOthman ZA.   +5 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Modeling, environmental and economic analysis of drying of orange slice in an automatic indirect mixed mode solar dryer. [PDF]

Sci Rep
Elwakeel AE, Oraiath AAT, Abdurraziq WAM, Elbeltagi A, Székács A, Saeed O, Eid MH, Al-Harbi MS, Ahmed AF, Tantawy AA.   +9 more
europepmc   +1 more source

Establishing an Open Probability-Based Mixed-Mode Panel of the General Population in Germany

, 2018
M. Bošnjak, Tanja Dannwolf, Tobias Enderle, Ines Schaurer, Bella Struminskaya, Angela Tanner, K. W. Weyandt   +6 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design and Implementation Process in a Pilot Project to Improve a Community Health Survey Using Mixed-mode Methods. [PDF]

Jugan Geongang Gwa Jilbyeong
Ko J, Lee KO, Hwang Y, Ko YS, Kim EK, Park C.   +5 more
europepmc   +1 more source