Results 61 to 70 of about 771,922 (316)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Design and Experimental Validation of the Versatile Voltage Conveyor-Based Novel Mixed-Mode Universal Filter Configurations and Quadrature Oscillator

Journal of Electrical and Computer Engineering
In this research, a truly mixed-mode multi-input single-output (MISO) universal filter is designed using a second-generation voltage conveyor (VCII) and an operational transconductance amplifier (OTA). The filter is designed with three VCIIs, three OTAs,
Mohammad Faseehuddin, Sadia Shireen, Orapin Channumsin, Mousumi Bhanja, Worapong Tangsrirat   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

A fast algorithm to racetrack filter multiaxial histories preserving load shape [PDF]

MATEC Web of Conferences, 2019
A fast algorithm is presented to implement a multiaxial version of the racetrack amplitude filter, improved upon the authors’ previous works. The algorithm only requires a single user-defined scalar filter amplitude to eliminate noise and potentially non-
Meggiolaro Marco Antonio, Pinho de Castro Jaime Tupiassú, Wu Hao   +2 more
doaj   +1 more source

A survey on OFDM-based elastic core optical networking [PDF]

, 2013
Orthogonal frequency-division multiplexing (OFDM) is a modulation technology that has been widely adopted in many new and emerging broadband wireless and wireline communication systems.
De Leenheer, Marc, Morea, A, Mukherjee, B, Zhang, GY   +3 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Recent advances on recursive filtering and sliding mode design for networked nonlinear stochastic systems: A survey [PDF]

, 2013
Copyright © 2013 Jun Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Some ...
Dong, H, Gao, H, Hu, J, Wang, Z
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Implementation of IMMPDAF Algorithm in LabVIEW for Multi Sensor Single Target Tracking [PDF]

, 2008
Real time IMMPDAF algorithm has been implemented and tested in LabVIEW. Single aircraft flight profiles have been simulated and the plot data from multiple radars observing the single aircraft are generated with noise as well as clutter. The performance
Girija, G, Naidu, VPS
core