Results 61 to 70 of about 255 (204)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Single VDCC-Based Mixed-Mode First-Order Universal Filter and Applications in Bio-Signal Processing Systems

Technologies
This paper presents a compact mixed-mode first-order universal filter based on a single voltage differencing current conveyor (VDCC), which can function in all four possible operation modes, i.e., voltage mode (VM), trans-admittance mode (TAM), current ...
Pitchayanin Moonmuang, Natchanai Roongmuanpha, Worapong Tangsrirat, Tattaya Pukkalanun   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

0.5 V BD-MIMO DDTA-Based Universal Multimode Biquad Filter

IEEE Access
A novel low-voltage universal mixed-mode filter that makes use of a multiple input/output differential difference transconductance amplifier (MIMO-DDTA) is presented in this study.
Chandra Shankar, Surekha Khened, B. Karunakara Rai, Fabian Khateb   +3 more
doaj   +1 more source

A Digital Image Denoising Algorithm Based on Gaussian Filtering and Bilateral Filtering

ITM Web of Conferences, 2018
Bilateral filtering has been applied in the area of digital image processing widely, but in the high gradient region of the image, bilateral filtering may generate staircase effect. Bilateral filtering can be regarded as one particular form of local mode
Piao Weiying, Yuan Yibao, Lin Haijun
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Design of Compact Bandpass Filters Using Novel Dual-Mode Dielectric Patch Resonator

IEEE Access, 2018
This paper introduces a new dual-mode dielectric patch resonator (DPR), which consists of a thin square dielectric patch with high permittivity and a low-permittivity substrate with bottom ground plane.
Jian-Xin Chen, Yun-Li Li, Wen-Wen Yang, Zhi-Hua Bao   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Adaptive Event-Triggered Mixed $H_{\infty}$ and Passivity-Based Filter Design for Nonlinear T-S Fuzzy Markovian Switching Systems With Time-Varying Delays

IEEE Access, 2019
This paper discusses the problem of mixed H∞ and passivity-based filter design for non-linear T-S Fuzzy Markovian Switching Systems (F-MSSs) with time-varying delays, under the adaptive event-triggered scheme. At first, an adaptive event-triggered
Muhammad Shamrooz Aslam, Ahmed Raza Rajput, Qianmu Li, Yaozong Liu, Shahab Ahmad Niazi   +4 more
doaj   +1 more source