Results 61 to 70 of about 1,655,427 (256)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Interspecific Conformity and Asymmetric Behavioral Convergence in Drosophila

open access: yesEcology and Evolution
Many animals form mixed‐species groups. Interactions among individuals within a group often induce behavioral conformity, forming group‐level characteristics.
Kaiya Hamamichi, Yuma Takahashi
doaj   +1 more source

Mixed bird flocks: patterns of activity and species composition in a region of the Central Andes of Colombia

open access: yesRevista Mexicana de Biodiversidad, 2011
Mixed bird flocks are groups of individuals from different species that travel and forage together. Such groups are common in several bird communities around the world. We present species composition and activity patterns of mixed bird flocks in a region
Enrique Arbeláez-Cortés   +2 more
doaj   +1 more source

The shoaling behavior of two cyprinid species in conspecific and heterospecific groups [PDF]

open access: yesPeerJ, 2017
Mixed-species shoals of fish are frequently found in the field; however, little is known about individual-level interactions within these groups. We examined the collective motion of two cyprinid species (Chinese bream, Parabramis pekinensis, and qingbo,
Zhong-Hua Tang   +4 more
doaj   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Composition of mixed-species bird flocks in forest fragments of southern Brazil

open access: yesZoologia (Curitiba), 2009
The present study aimed to evaluate the composition of mixed-species bird flocks in a fragmented landscape of the Atlantic Forest in southern Brazil. We recorded 117 species in 218 mixed-species flocks.
Cláudia S. Brandt   +3 more
doaj   +1 more source

Factors Affecting Group Spread within Wild Mixed-Species Troops of Saddleback and Mustached Tamarins [PDF]

open access: yesInternational Journal of Primatology, 2005
We examined group spread and interindividual spacing within wild mixed species troops of saddleback (Saguinus fuscicollis) and mustached (Saguinus mystax) tamarins. Mustached tamarin groups were spread over larger areas than those of saddleback tamarins.
Smith, Andrew C   +3 more
openaire   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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