Results 61 to 70 of about 897,258 (243)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Foraging ecology of common dolphins (Delphinus sp.) in the Hauraki Gulf, New Zealand : a thesis presented in fulfilment of the requirements for the degree of Master of Science (Zoology), Massey University, Albany, New Zealand [PDF]

, 2006
This study investigated the foraging ecology of common dolphins (Delphinus sp.) in the Hauraki Gulf Marine Park, off the east coast of Auckland. New Zealand.
Burgess, Elizabeth A
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Reporting social behaviours of mixed-species troops formed by Callithrix jacchus and Callithrix penicillata (Primate, Callitrichidae)

Brazilian Journal of Biology
In New World primates, mixed-species troops have been reported. Here, we analysed the performance of affiliative and agonistic behaviours of Callithrix jacchus and Callithrix penicillata living in mixed groups.
G Valença-Silva, FG Maciel, RL Zaganini, AS Lucindo, S Caramaschi, HMG. de Paula   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Foe You Know: Observations of Interspecific Interactions Between Small Cetaceans and Northern Resident Killer Whales (Orcinus orca) in the Northeast Pacific

Ecology and Evolution
We documented the first aerial observations of interspecific interactions of fish‐eating, northern resident killer whales (Orcinus orca) with two small cetacean species, Dall's porpoises (Phocoenoides dalli) and Pacific white‐sided dolphins ...
Brittany C. Visona‐Kelly, Lance G. Barrett‐Lennard   +1 more
doaj   +1 more source

Prevalence and proportion of Plasmodium spp. triple mixed infections compared with double mixed infections: a systematic review and meta-analysis

Malaria Journal, 2020
Background Although mixed infection by two Plasmodium species has been recognized, mixed infection by three different Plasmodium species within one individual has not been clarified.
Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez, Frederick R. Masangkay   +3 more
doaj   +1 more source

Stand-level drivers of tree-species diversification in Mediterranean pine forests after abandonment of traditional practices [PDF]

, 2015
The progressive abandonment of traditional forest management over the last few decades has led to significant densification processes in most Mediterranean pine stands.
Coll Mir, Lluís, Martín Alcón, Santiago, Salekin, Serajis   +2 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source