Results 101 to 110 of about 4,674,587 (322)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

AUFS-Samba: Adaptive Unsupervised Feature Selection for Mixed Data Type Using Simulated Annealing and Multi-Armed Bandit

IEEE Access
Unsupervised feature selection (UFS) for mixed-type data is challenging because there are no labels, and traditional methods cannot handle heterogeneous feature spaces effectively.
Hasta Pratama, Fetty Fitriyanti Lubis, Jaka Sembiring   +2 more
doaj   +1 more source

Differential Responders to a Mixed Meal Tolerance Test Associated with Type 2 Diabetes Risk Factors and Gut Microbiota—Data from the MEDGI-Carb Randomized Controlled Trial [PDF]

, 2023
Viktor Skantze, Thérése Hjorth, Mikael Wallman, Carl Brunius, Johan Dicksved, Erik A. Pelve, Anders Esberg, Marilena Vitale, Rosalba Giacco, Giuseppina Costabile, Robert Bergia, Mats Jirstrand, W. W. Campbell, Gabriele Riccardi, Rikard Landberg   +14 more
openalex   +1 more source

Sensitivity and robustness in MDS configurations for mixed-type data: a study of the economic crisis impact on socially vulnerable Spanish people [PDF]

Multidimensional scaling (MDS) techniques are initially proposed to produce pictorial representations of distance, dissimilarity or proximity data. Sensitivity and robustness assessment of multivariate methods is essential if inferences are to be drawn ...
Aurea Grané, Rosario Romera
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effect of different sowing densities in mixed cultivation of blue lupin (Lupinus angustifolius) with spring crops on yield and quality [PDF]

, 2008
The aim of this investigation was to optimise the yield percentage of blue lupins in mixed cropping systems. Field experiments were conducted at two locations in Northern Germany (Institute of Organic Farming near Hamburg and Institute of Plant and Soil ...
Aulrich, Karen, Bramm, Andreas, Böhm, Herwart, Rühl, Gerhard   +3 more
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Exploiting mutual information for the imputation of static and dynamic mixed-type clinical data with an adaptive k-nearest neighbours approach [PDF]

, 2020
Erica Tavazzi, Sebastian Daberdaku, Rosario Vasta, Andrea Calvo, Adriano Chiò, Barbara Di Camillo   +5 more
openalex   +1 more source

Type-I superconductivity in noncentrosymmetric superconductor AuBe

, 2019
The noncentrosymmetric superconductor AuBe have been investigated using the magnetization, resistivity, specific heat, and muon-spin relaxation/rotation measurements.
Hillier, A. D., Singh, D., Singh, R. P.
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source