Results 111 to 120 of about 4,503,666 (319)
International Journal of Technology, 2016 Aluminum alloys, such as A6061-T6, are widely used in engineering components. However, detailed knowledge is needed to understand the way they respond to a fracture due to mechanical loading.
Husaini, Zuhaimi
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Effect of different sowing densities in mixed cultivation of blue lupin (Lupinus angustifolius) with spring crops on yield and quality [PDF]
, 2008 The aim of this investigation was to optimise the yield percentage of blue lupins in mixed cropping systems. Field experiments were conducted at two locations in Northern Germany (Institute of Organic Farming near Hamburg and Institute of Plant and Soil ...
Aulrich, Karen +3 more
core
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Use of mixed-type data clustering algorithm for characterizing temporal and spatial distribution of biosecurity border detections of terrestrial non-indigenous species. [PDF]
PLoS One, 2022 Kachigunda B +5 more
europepmc +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
Allergology International, 2017 Background: We previously reported the results of lung sound analysis in patients with bronchial asthma and demonstrated that the exhalation-to-inhalation sound pressure ratio in the low frequency range between 100 and 200 Hz (E/I LF) was correlated with
Terufumi Shimoda +5 more
doaj +1 more source
Spitzer detection of PAH and silicate features in post-AGB stars and young Planetary Nebulae
, 2009 We have observed a small sample of hot post-AGB stars with the InfraRed Array Camera (IRAC) and the InfraRed Spectrograph (IRS) on-board the Spitzer Space Telescope. The stars were selected from the literature on the basis of their far-Infrared excess (i.
Cerrigone +30 more
core +1 more source